Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan.
Front Public Health. 2024 Feb 21;12:1352570. doi: 10.3389/fpubh.2024.1352570. eCollection 2024.
Glyphosate, a widely utilized herbicide globally, has been linked to various health issues, including cancer, birth abnormalities, and reproductive issues. Additionally, there is growing experimental support indicating potential harm to skeletal muscles. Despite this, the impact of glyphosate on human muscle health remains unclear.
We examined information gathered from the 2013-2014 National Health and Nutrition Examination Survey (NHANES), which included 1466 adults aged 18 or older. Our primary aim was to investigate the relationship between glyphosate exposure and hand grip strength, as well as its influence on lean muscle mass.
Our investigation uncovered a detrimental correlation between glyphosate exposure and all measures of grip strength, except for the second test of the first hand. Specifically, we observed a statistically significant adverse association between glyphosate exposure and combined grip strength, which is calculated as the sum of the highest readings from both hands (ß coefficient of -2.000, S.E. = 0.891, = 0.040). We did not observe a significant correlation between glyphosate levels, lean muscle mass, and the likelihood of reaching maximum grip strength meeting sarcopenia criteria. Additionally, we observed an interaction between age and glyphosate, as well as between body mass index (BMI) and glyphosate, concerning the association with combined grip strength. In this comprehensive analysis of NHANES data, our study reveals a potential association between glyphosate exposure and hand grip strength in the adult population. Our findings suggest the need for deeper exploration into the health effects of glyphosate exposure and its impact on muscle strength, shedding light on possible public health concerns.
草甘膦是一种全球广泛使用的除草剂，已与多种健康问题相关联，包括癌症、出生缺陷和生殖问题。此外，越来越多的实验证据表明它可能对骨骼肌造成损害。尽管如此，草甘膦对人类肌肉健康的影响仍不清楚。
我们研究了 2013-2014 年全国健康和营养调查（NHANES）的数据，该调查包括 1466 名 18 岁或以上的成年人。我们的主要目的是调查草甘膦暴露与手握力之间的关系，以及它对瘦肌肉质量的影响。
我们的研究发现，草甘膦暴露与所有握力测量值之间存在有害相关性，除了第一只手的第二次测试外。具体而言，我们观察到草甘膦暴露与总握力之间存在统计学上显著的不利关联，总握力是两只手最高读数的总和（β系数为-2.000，标准误为 0.891，p=0.040）。我们没有观察到草甘膦水平、瘦肌肉质量和达到最大握力满足肌少症标准的可能性之间存在显著相关性。此外，我们观察到年龄和草甘膦之间以及体重指数（BMI）和草甘膦之间存在交互作用，与总握力相关。在对 NHANES 数据的全面分析中，我们的研究揭示了草甘膦暴露与成年人口手握力之间的潜在关联。我们的研究结果表明，需要更深入地探讨草甘膦暴露对健康的影响及其对肌肉力量的影响，以揭示可能存在的公共卫生问题。
