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多组学技术在职业性噪声性听力损失易感性中的应用及前景

[Application and prospect of multiomics techniques in susceptibility to occupational noise hearing loss].

作者信息

Cui Y N, Yu S F

机构信息

Department of Occupational Health and Occupational Disease, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.

Department of Scientific Research and Foreign Affairs, Henan Medical College, Zhengzhou 451191, China.

出版信息

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 Sep 20;39(9):704-708. doi: 10.3760/cma.j.cn121094-20201022-00594.

Abstract

With the continuous innovation of technology, genomics and other omics techniques, such as transcriptomics, proteomics, and metabolomics, are increasingly becoming an important basis for precision medicine. Current research on susceptibility to occupational noise hearing loss (ONHL) has focused on genomics. Building the future of precision medicine is the focus of current ONHL research. Compared to single-omics studies, the use of multi-omics analysis can provide an integrated flow of information on ONHL susceptibility. This paper outlines the advantages and limitations of different histological techniques and the application of each histology in the disease, and focuses on the feasibility of applying multi-omics techniques in ONHL susceptibility research. The analysis of multi-omics techniques can better guide the comprehensive understanding of the disease in clinical research.

摘要

随着技术、基因组学以及其他组学技术(如转录组学、蛋白质组学和代谢组学)的不断创新,这些技术正日益成为精准医学的重要基础。目前关于职业性噪声性听力损失(ONHL)易感性的研究主要集中在基因组学方面。构建精准医学的未来是当前ONHL研究的重点。与单一组学研究相比,多组学分析的应用能够提供关于ONHL易感性的综合信息流。本文概述了不同组织学技术的优缺点以及每种组织学在该疾病中的应用,并着重探讨了多组学技术应用于ONHL易感性研究的可行性。多组学技术分析能够更好地指导临床研究中对该疾病的全面理解。

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