University of Alberta and Stollery Children's Hospital, Division of Pediatric Critical Care, Edmonton, Alberta, Canada.
University of Alberta, John Dossetor Health Ethics Center, 4-546 Edmonton Clinic Health Academy, 11405 112 Street, Edmonton, Alberta, T6G 1C9, Canada.
Philos Ethics Humanit Med. 2021 Oct 9;16(1):11. doi: 10.1186/s13010-021-00107-9.
Brain death has been accepted worldwide medically and legally as the biological state of death of the organism. Nevertheless, the literature has described persistent problems with this acceptance ever since brain death was described. Many of these problems are not widely known or properly understood by much of the medical community. Here we aim to clarify these issues, based on the two intractable problems in the brain death debates. First, the metaphysical problem: there is no reason that withstands critical scrutiny to believe that BD is the state of biological death of the human organism. Second, the epistemic problem: there is no way currently to diagnose the state of BD, the irreversible loss of all brain functions, using clinical tests and ancillary tests, given potential confounders to testing. We discuss these problems and their main objections and conclude that these problems are intractable in that there has been no acceptable solution offered other than bare assertions of an 'operational definition' of death. We present possible ways to move forward that accept both the metaphysical problem - that BD is not biological death of the human organism - and the epistemic problem - that as currently diagnosed, BD is a devastating neurological state where recovery of sentience is very unlikely, but not a confirmed state of irreversible loss of all [critical] brain functions. We argue that the best solution is to abandon the dead donor rule, thus allowing vital organ donation from patients currently diagnosed as BD, assuming appropriate changes are made to the consent process and to laws about killing.
脑死亡已被全球医学界和法律界接受为生物死亡的器官状态。然而,自从脑死亡被描述以来,文献中一直描述了与之相关的持续存在的问题。这些问题中的许多问题并没有被医学界的大多数人广泛了解或正确理解。在这里,我们旨在根据脑死亡辩论中的两个棘手问题来澄清这些问题。首先,形而上学问题:没有经得起批判性审查的理由相信 BD 是人类器官的生物死亡状态。其次,认识论问题:目前没有办法使用临床测试和辅助测试来诊断 BD(所有大脑功能不可逆丧失)的状态,因为测试存在潜在的混杂因素。我们讨论了这些问题及其主要反对意见,并得出结论,这些问题是棘手的,因为除了对死亡的“操作定义”的断言之外,没有提出其他可接受的解决方案。我们提出了可能的前进方向,既承认形而上学问题 - BD 不是人类器官的生物死亡 - 也承认认识论问题 - 目前诊断为 BD 是一种毁灭性的神经状态,意识恢复的可能性非常小,但不是所有[关键]大脑功能不可逆丧失的确认状态。我们认为,最好的解决方案是放弃已故供体规则,从而允许从目前被诊断为 BD 的患者中进行重要器官捐赠,前提是对同意过程和关于杀戮的法律进行适当修改。