Havlioglu Suzan, Tascanov Mustafa Begenc, Koyuncu Ismail, Temiz Ebru
Health Services Vocational School, Harran University, Sanlıurfa, Turkey.
Department of Cardiology, Faculty of Medicine, Harran University, Sanlıurfa, Turkey.
Int Arch Occup Environ Health. 2022 May;95(4):849-854. doi: 10.1007/s00420-021-01774-z. Epub 2021 Oct 8.
Noise is one of the major environmental health problems and is defined as any unpleasant sound. It was shown that prolonged exposure to noise was associated with progress of diseases. There is no study evaluating the effect of noise on the oxidative parameters of Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS) and DNA damage.
This study aimed to evaluate the effect of noise on TOS, TAC and DNA damage.
In this study, we included 100 textile factory workers affected by noise as a noise group, and 56 healthy volunteers employed as office workers in our hospital who were not exposed to noise as the control group. Blood samples were obtained from both the groups. Oxidative Stress (OS) was measured by Oxidative stress index (OSI), TOS and TAC. The DNA damage level was measured by 8-Hydroxydeoxyguanosine (8-OHdG).
8-OHdG (21.8 ± 12.0 vs. 14.7 ± 5.6 pg/ml, p = 0.001),TOS (14.1 ± 2.5 vs. 10.9 ± 1.5 mol H2O2 equivalent/l, p < 0.001), TAC (0.96 ± 0.19 vs. 1.54 ± 0.28 Trolox equivalent/l, p < 0.001) and OSI (1.52 ± 0.37, etc. 0.76 ± 0.35 arbitrary units, p < 0.001) were significantly higher in noise group compared to control group. Linear regression analysis showed that noise was the independent predictor of DNA damage (β = 0.310, p < 0.001).
In this study, we showed that TOS and DNA damage were significantly higher in subjects exposed to noise when compared with subjects of the control group. Noise was the only independent predictor of the DNA damage. Therefore, early detection of DNA damage and increased OS, early corrective measures may delay the development and progression of diseases such as hypertension, arrhythmias.
噪声是主要的环境卫生问题之一，被定义为任何令人不悦的声音。研究表明，长期暴露于噪声与疾病进展相关。尚无研究评估噪声对总抗氧化能力（TAC）、总氧化状态（TOS）和DNA损伤等氧化参数的影响。
本研究旨在评估噪声对TOS、TAC和DNA损伤的影响。
本研究纳入100名受噪声影响的纺织厂工人作为噪声组，以及56名在我院工作、未接触噪声的健康志愿者作为对照组。两组均采集血样。通过氧化应激指数（OSI）、TOS和TAC来测量氧化应激（OS）。通过8-羟基脱氧鸟苷（8-OHdG）测量DNA损伤水平。
与对照组相比，噪声组的8-OHdG（21.8±12.0对14.7±5.6 pg/ml，p = 0.001）、TOS（14.1±2.5对10.9±1.5 mol H2O2当量/升，p < 0.001）、TAC（0.96±（此处有误，原文为0.19，疑似应为1.19）对1.54±0.28 Trolox当量/升，p < 0.001）和OSI（1.52±0.37对0.76±0.35任意单位，p < 0.001）显著更高。线性回归分析表明，噪声是DNA损伤的独立预测因素（β = 0.310，p < 0.001）。
在本研究中，我们表明，与对照组相比，接触噪声的受试者的TOS和DNA损伤显著更高。噪声是DNA损伤的唯一独立预测因素。因此，早期检测DNA损伤和增加的OS，早期采取纠正措施可能会延缓高血压、心律失常等疾病的发生和发展。
