口腔细菌的发病机制与抑制剂治疗。
The pathogenic mechanism of oral bacteria and treatment with inhibitors.
机构信息
Henry M. Goldman School of Dental Medicine, Department of Periodontology, Boston University, Boston, Massachusetts, USA.
Department of Corporate Finance and Accounting, Bentley University, Waltham, Massachusetts, USA.
出版信息
Clin Exp Dent Res. 2022 Feb;8(1):439-448. doi: 10.1002/cre2.499. Epub 2021 Oct 9.
OBJECTIVES
The objective of this study was to introduce the evidence obtained through extensive research that periodontitis increases risk of many systemic diseases.
METHOD
Analysis of some oral bacteria (P. gingivalis, T. denticola, T. forsythia, A. actinomycetemcomitans, and F. nucleatum) and its related treatments and mediators by the specific methods (western blot, ELISA, etc).
RESULTS
This article reviews in detail the evidence obtained through extensive research that periodontitis increases risk of many systemic diseases, including cardiovascular disease, rheumatoid arthritis, and Alzheimer's disease. These diseases are known to be associated with some certain specific gram-negative bacteria as periodontal pathogens, which induce inflammation and related diseases through TLR receptors, kinases, transcriptional factors and other cytokines. We also reviewed the latest research for inhibitors against inflammation and related diseases that have potential to be further applied clinically. In addition, based on a large amount of research evidence, we draw two tables about the mechanism of disease caused by periodontal bacteria, so that readers can easily search and analyze these research results.
DISCUSSION
This review details how the periodontal bacteria and their virulence factors can trigger host immune defense and induce many systemic diseases via inflammation and invasion. This Review also addressed the latest research around inhibitors against inflammation.
目的
本研究旨在介绍通过广泛研究获得的证据，即牙周炎会增加许多系统性疾病的风险。
方法
通过特定方法（western blot、ELISA 等）分析一些口腔细菌（牙龈卟啉单胞菌、伴放线放线杆菌、福赛斯坦纳菌、中间普氏菌和核梭杆菌）及其相关治疗和介质。
结果
本文详细回顾了通过广泛研究获得的证据，即牙周炎会增加许多系统性疾病的风险，包括心血管疾病、类风湿性关节炎和阿尔茨海默病。这些疾病已知与某些特定的革兰氏阴性细菌（牙周病原体）有关，这些细菌通过 TLR 受体、激酶、转录因子和其他细胞因子引起炎症和相关疾病。我们还回顾了针对炎症和相关疾病的抑制剂的最新研究，这些抑制剂具有进一步临床应用的潜力。此外，基于大量的研究证据，我们绘制了两张关于牙周细菌引起疾病的机制的表，以便读者可以方便地搜索和分析这些研究结果。
讨论
本综述详细介绍了牙周细菌及其毒力因子如何通过炎症和侵袭引发宿主免疫防御并诱导许多系统性疾病。本综述还讨论了针对炎症的最新研究。
Zotero 插件