牙周炎与阿尔茨海默病之间的潜在机制：范围综述。
Potential mechanisms between periodontitis and Alzheimer's disease: a scoping review.
机构信息
Assistant clinical professor in dentistry, University of Indiana School of Dentistry, Indianapolis, IN, USA.
Clinical lecturer in dentistry, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
出版信息
Can J Dent Hyg. 2023 Feb 1;57(1):52-60. eCollection 2023 Feb.
BACKGROUND
Research has suggested 2 potential mechanisms by which the periodontal inflammatory response may communicate to distant organs: 1) direct translocation of periodontal bacteria from the oral cavity to another organ system; and 2) inflammation as a result of metastatic periodontal inflammation. The purpose of this scoping review is to explore these mechanisms as potential mediators between periodontitis and Alzheimer's disease.
METHODS
A reiterative literature search of peer-reviewed articles was performed in the PubMed and Scopus databases using keywords or combinations such as Alzheimer's disease AND periodontitis OR periodontal disease AND inflammation.
RESULTS
A total of 777 articles were identified. After eliminating duplicates and reviewing titles and abstracts, 84 articles were selected for full-text review. Following full-text review, 19 articles met the eligibility criteria for the study.
DISCUSSION
The review of the literature highlights how periodontitis may contribute to neuroinflammation by the introduction of periodontal bacteria and/or proinflammatory cytokines locally produced at the periodontium.
CONCLUSION
Inflammation is an important mechanism in the onset and progression of both periodontitis and Alzheimer's disease. Nevertheless, further studies are necessary to better understand the multifactorial pathogenesis of Alzheimer's disease.
背景
研究提出了牙周炎炎症反应可能向远处器官传递的两种潜在机制：1）牙周细菌从口腔直接转移到另一个器官系统；2）转移性牙周炎炎症引起的炎症。本范围综述的目的是探讨这些机制作为牙周炎和阿尔茨海默病之间的潜在介质。
方法
使用关键词或组合（如阿尔茨海默病和牙周炎或牙周病和炎症）在 PubMed 和 Scopus 数据库中重复进行同行评审文献搜索。
结果
共确定了 777 篇文章。消除重复项并审查标题和摘要后，选择了 84 篇文章进行全文审查。全文审查后，有 19 篇文章符合研究标准。
讨论
文献综述强调了牙周炎如何通过在牙周局部产生的牙周细菌和/或促炎细胞因子来引发神经炎症。
结论
炎症是牙周炎和阿尔茨海默病发病和进展的重要机制。然而，需要进一步的研究来更好地了解阿尔茨海默病的多因素发病机制。
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