Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, 21205, USA.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
AIDS Behav. 2022 Apr;26(4):1299-1307. doi: 10.1007/s10461-021-03487-3. Epub 2021 Oct 9.
We estimated joint associations between having history of alcohol use disorder (AUD) (based on prior ICD-9/ICD-10 codes) and recent self-reported alcohol use and viral non-suppression (≥ 1 viral load measurement > 20 copies/mL in the same calendar year as alcohol consumption was reported) among patients on ART enrolled in routine care, 2014-2018, in an urban specialty clinic. Among 1690 patients, 26% had an AUD, 21% reported high-risk alcohol use, and 39% had viral non-suppression. Relative to person-years in which people without AUD reported not drinking, prevalence of viral non-suppression was higher in person-years when people with AUD reported drinking at any level; prevalence of viral non-suppression was not significantly higher in person-years when people with AUD reported not drinking or person-years when people without AUD reported drinking at any level. No level of alcohol use may be "safe" for people with a prior AUD with regard to maintaining viral suppression.
我们评估了在接受常规护理的 ART 患者中，2014 年至 2018 年，根据先前的 ICD-9/ICD-10 编码（基于既往酒精使用障碍（AUD）病史）和最近的自我报告的酒精使用与病毒未抑制（同一年度报告饮酒的情况下，有≥1 次病毒载量测量值>20 拷贝/ml）之间的联合关联。在 1690 名患者中，26%有 AUD，21%报告有高危饮酒，39%有病毒未抑制。与没有 AUD 的人报告不饮酒的人年相比，在 AUD 患者报告饮酒的任何水平的人年中，病毒未抑制的流行率更高；在 AUD 患者报告不饮酒的人年或没有 AUD 的人报告饮酒的任何水平的人年中，病毒未抑制的流行率没有显著更高。对于有既往 AUD 的人来说，任何水平的饮酒都可能不安全，无法维持病毒抑制。
