Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Ann Epidemiol. 2023 Sep;85:6-12. doi: 10.1016/j.annepidem.2023.07.002. Epub 2023 Jul 12.
We described the impact of alcohol use on longitudinal engagement in HIV care including loss to follow-up, durability of viral suppression, and death.
We followed a cohort of 1781 people with HIV from enrolled in care at one of seven US clinics, 2011-2019 through 102 months. We used a multistate, time-varying Markov process and restricted mean time to summarize engagement in HIV care over follow-up according to baseline self-reported alcohol use (none, moderate, or unhealthy).
Our sample (86% male, 54% White) had median age of 35 years. Over 102 months, people with no, moderate, and unhealthy alcohol use averaged 62.3, 61.1, and 59.5 months virally suppressed, respectively. People who reported unhealthy or moderate alcohol use spent 5.1 (95% confidence intervals (CI): 0.8, 9.3) and 7.6 (95%CI: 3.1, 11.7) more months lost to care than nondrinkers. Compared to no use, unhealthy alcohol use was associated with 3.4 (95%CI: -5.6, -1.6) fewer months in care, not virally suppressed. There were no statistically significant differences after adjustment for demographic and clinical characteristics.
Moderate or unhealthy drinking at enrollment in HIV care was associated with poor retention in care. Alcohol use was not associated with time spent virally suppressed.
我们描述了酒精使用对 HIV 护理纵向参与的影响,包括失访、病毒抑制的持久性和死亡。
我们对 1781 名于 2011 年至 2019 年期间在七个美国诊所之一接受护理的 HIV 感染者进行了队列研究,随访 102 个月。我们使用多状态、时变马尔可夫过程和限制平均时间来根据基线自我报告的酒精使用情况(无、中度或不健康)总结 HIV 护理参与情况。
我们的样本(86%为男性,54%为白人)的中位年龄为 35 岁。在 102 个月的随访期间,无、中度和不健康饮酒者的病毒抑制平均时间分别为 62.3、61.1 和 59.5 个月。报告有不健康或中度饮酒的患者在护理中失访的时间比不饮酒的患者分别多 5.1 个月(95%置信区间(CI):0.8,9.3)和 7.6 个月(95%CI:3.1,11.7)。与不饮酒相比,不健康饮酒与护理时间减少 3.4 个月(95%CI:-5.6,-1.6)相关,而非病毒抑制时间。在调整人口统计学和临床特征后,差异无统计学意义。
在开始接受 HIV 护理时,中度或不健康的饮酒与护理保留率差有关。饮酒与病毒抑制时间无关。