印度孟买第三代头孢菌素耐药伤寒沙门氏菌的传播。
Circulation of Third-Generation Cephalosporin Resistant Salmonella Typhi in Mumbai, India.
机构信息
Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
Central Research Laboratory, Kempegowda Institute of Medical Sciences, Bengaluru, India.
出版信息
Clin Infect Dis. 2022 Jul 6;74(12):2234-2237. doi: 10.1093/cid/ciab897.
Abstract
We report the persistent circulation of third-generation cephalosporin resistant Salmonella Typhi in Mumbai, linked to the acquisition and maintenance of a previously characterized IncX3 plasmid carrying the ESBL gene blaSHV-12 and the fluoroquinolone resistance gene qnrB7 in the genetic context of a triple mutant also associated with fluoroquinolone resistance.
摘要
我们报告了第三代头孢菌素耐药伤寒沙门氏菌在孟买的持续传播，这与携带 ESBL 基因 blaSHV-12 和氟喹诺酮耐药基因 qnrB7 的先前特征化 IncX3 质粒的获得和维持有关，该质粒的遗传背景还与氟喹诺酮耐药相关的三重突变体有关。
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