London School of Hygiene & Tropical Medicine, London, United Kingdom.
Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
J Infect Dis. 2021 Dec 20;224(12 Suppl 2):S775-S780. doi: 10.1093/infdis/jiab414.
In 2016, a whole-genome sequence (WGS)-based genotyping framework (GenoTyphi) was developed and provided a phylogenetically informative nomenclature for lineages of Salmonella Typhi, the etiological agent of typhoid fever. Subsequent surveillance studies have revealed additional epidemiologically important subpopulations, which require the definition of new genotypes and extension of associated software to facilitate the detection of antimicrobial resistance (AMR) mutations. Analysis of 4632 WGS provide an updated overview of the global S Typhi population structure and genotyping framework, revealing the widespread nature of haplotype 58 ([H58] 4.3.1) genotypes and the diverse range of genotypes carrying AMR mutations.
2016 年，开发了一种基于全基因组序列（WGS）的基因分型框架（GenoTyphi），为伤寒沙门氏菌（引起伤寒的病原体）的谱系提供了具有系统发育信息的命名法。随后的监测研究揭示了其他具有重要流行病学意义的亚群，这需要定义新的基因型，并扩展相关软件，以方便检测抗生素耐药性（AMR）突变。对 4632 个 WGS 的分析提供了全球 S Typhi 种群结构和基因分型框架的最新概述，揭示了单倍型 58 ([H58] 4.3.1) 基因型的广泛存在以及携带 AMR 突变的多种基因型。
