Liu Wei, Liu Xin, Kang Shiwei, Yuan Yadong
First Department of Pulmonary and Critical Care Medicine, Hebei Chest Hospital, Shijiazhuang, China.
Second Department of Pulmonary and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Front Nutr. 2025 Apr 7;12:1476622. doi: 10.3389/fnut.2025.1476622. eCollection 2025.
To provide further data support for the treatment of COVID-19 by conducting a comprehensive analysis of reports on dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which detects the functional vitamin K status post COVID-19 infection, using meta-analysis.
This study conducted a comprehensive review and analysis of relevant research on dp-ucMGP detection in patients infected with COVID-19 through meta-analysis. The article collection period ranged from January 2024 to April 2024.
A total of 6 articles were included in this study. Baseline data analysis showed that the age of patients in the COVID-19 infected group was greater than that of the non-infected control group ( = 0.030); similarly, the age of patients in the severe infection group was also greater than that of the mild infection group ( = 0.003). In the analysis of underlying diseases, statistical differences were found between the Severe group and Mild group in the presence of CVD ( = 0.010). A total of 5 studies conducted dp-ucMGP detection in both the COVID-19 infected group and the control group. The results showed that the expression of dp-ucMGP was higher in the infected group than in the control group ( < 0.001). Subgroup analysis revealed that the expression of dp-ucMGP in the severe infection group was also higher than that in the mild infection group ( < 0.001).
COVID-19 infected patients exhibit Low Vitamin K Status, which correlates positively with the severity of infection. Supplementation of vitamin K during COVID-19 infection may potentially mitigate the progression toward severe infection, necessitating further support from clinical data.
通过对去磷酸化未羧化基质Gla蛋白（dp-ucMGP）报告进行综合分析，采用荟萃分析检测新冠病毒感染后功能性维生素K状态，为新冠病毒疾病（COVID-19）的治疗提供进一步的数据支持。
本研究通过荟萃分析对新冠病毒感染患者dp-ucMGP检测的相关研究进行了全面回顾和分析。文章收集期为2024年1月至2024年4月。
本研究共纳入6篇文章。基线数据分析显示，新冠病毒感染组患者的年龄大于未感染对照组（P = 0.030）；同样，重症感染组患者的年龄也大于轻症感染组（P = 0.003）。在基础疾病分析中，重症组和轻症组在存在心血管疾病方面存在统计学差异（P = 0.010）。共有5项研究在新冠病毒感染组和对照组中均进行了dp-ucMGP检测。结果显示，感染组中dp-ucMGP的表达高于对照组（P < 0.001）。亚组分析显示，重症感染组中dp-ucMGP的表达也高于轻症感染组（P < 0.001）。
新冠病毒感染患者表现出低维生素K状态，这与感染的严重程度呈正相关。在新冠病毒感染期间补充维生素K可能会减轻向重症感染进展的程度，这需要临床数据的进一步支持。
