Institut Pasteur, Université de Paris, CNRS UMR3738, Department of Developmental and Stem Cell Biology, F-75015 Paris, France; Sorbonne Université, Collège Doctoral, F75005 Paris, France.
Institut Pasteur, Université de Paris, CNRS UMR3738, Department of Developmental and Stem Cell Biology, F-75015 Paris, France.
Curr Opin Genet Dev. 2022 Feb;72:8-14. doi: 10.1016/j.gde.2021.09.004. Epub 2021 Oct 6.
Programmed cell death, notably apoptosis, is an essential guardian of tissue homeostasis and an active contributor of organ shaping. While the regulation of apoptosis has been mostly analysed in the framework of a cell autonomous process, recent works highlighted important collective effects which can tune cell elimination. This is particularly relevant for epithelial cell death, which requires fine coordination with the neighbours in order to maintain tissue sealing during cell expulsion. In this review, we will focus on the recent advances which outline the complex multicellular communications at play during epithelial cell death and cell extrusion. We will first focus on the new unanticipated functions of neighbouring cells during extrusion, discuss the contribution of distant neighbours, and finally highlight the complex feedbacks generated by cell elimination on neighbouring cell death.
程序性细胞死亡，尤其是细胞凋亡，是组织动态平衡的重要守护者，也是器官形成的积极贡献者。虽然凋亡的调节主要在细胞自主过程的框架内进行分析，但最近的研究工作强调了可以调节细胞清除的重要集体效应。这对于上皮细胞死亡尤其重要，上皮细胞死亡需要与邻居进行精细协调，以在细胞排出过程中保持组织密封。在这篇综述中，我们将重点介绍最近的进展，这些进展概述了上皮细胞死亡和细胞排出过程中发挥作用的复杂细胞间通讯。我们将首先关注在挤出过程中相邻细胞的新的意外功能，讨论远邻的贡献，最后强调细胞清除对相邻细胞死亡产生的复杂反馈。
