Ifakara Health Institute, PO Box 78373, Dar es Salaam, Tanzania.
London School of Hygiene and Tropical Medicine, Faculty of Epidemiology and Population Health, Keppel Street, London, UK.
Antimicrob Resist Infect Control. 2021 Oct 9;10(1):142. doi: 10.1186/s13756-021-01014-6.
Overuse of antibiotics is a major challenge and undermines measures to control drug resistance worldwide. Postnatal women and newborns are at risk of infections and are often prescribed prophylactic antibiotics although there is no evidence to support their universal use in either group.
We performed point prevalence surveys in three hospitals in Dar es Salaam, Tanzania, in 2018 to collect descriptive data on antibiotic use and infections, in maternity and neonatal wards.
Prescribing of antibiotics was high in all three hospitals ranging from 90% (43/48) to 100% (34/34) in women after cesarean section, from 1.4% (1/73) to 63% (30/48) in women after vaginal delivery, and from 89% (76/85) to 100% (77/77) in neonates. The most common reason for prescribing antibiotics was medical prophylaxis in both maternity and neonatal wards.
We observed substantial overuse of antibiotics in postnatal women and newborns. This calls for urgent antibiotic stewardship programs in Tanzanian hospitals to curb this inappropriate use and limit the spread of antimicrobial resistance.
抗生素的过度使用是一个主要的挑战，破坏了全球控制耐药性的措施。产后妇女和新生儿面临感染的风险，经常预防性地使用抗生素，尽管没有证据支持这两组人群普遍使用抗生素。
我们于 2018 年在坦桑尼亚达累斯萨拉姆的三家医院进行了时点患病率调查，以收集关于产妇和新生儿病房中抗生素使用和感染的描述性数据。
在所有三家医院中，剖宫产术后妇女的抗生素处方率均较高，范围从 90%（43/48）至 100%（34/34），阴道分娩后妇女的抗生素处方率从 1.4%（1/73）至 63%（30/48），新生儿的抗生素处方率从 89%（76/85）至 100%（77/77）。在产妇和新生儿病房中，开具抗生素的最常见原因是医疗预防。
我们观察到产后妇女和新生儿中抗生素的大量过度使用。这呼吁坦桑尼亚医院紧急采取抗生素管理计划，以遏制这种不适当的使用并限制抗菌药物耐药性的传播。
