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IL-6 antagonists to replace systemic corticosteroids as the preferred anti-inflammatory therapy in patients with COVID-19?白细胞介素-6拮抗剂能否取代全身用皮质类固醇，成为新冠病毒病患者首选的抗炎治疗药物？
Cytokine. 2022 Jan;149:155730. doi: 10.1016/j.cyto.2021.155730. Epub 2021 Oct 5.
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Unresolved questions about the treatment of COVID-19 with corticosteroids.关于使用皮质类固醇治疗新冠病毒病（COVID-19）的未解决问题。
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Early identification of COVID-19 cytokine storm and treatment with anakinra or tocilizumab.早期识别 COVID-19 细胞因子风暴并使用阿那白滞素或托珠单抗治疗。
Int J Infect Dis. 2020 Oct;99:291-297. doi: 10.1016/j.ijid.2020.07.081. Epub 2020 Aug 6.

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Glucocorticoid therapy in patients with COVID-19 and concurrent heart failure.新冠病毒病合并心力衰竭患者的糖皮质激素治疗
Rev Clin Esp (Barc). 2022 May;222(5):309-310. doi: 10.1016/j.rceng.2021.11.002. Epub 2022 Jan 31.
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[Glucocorticoid therapy in patients with COVID-19 and concurrent heart failure].[新型冠状病毒肺炎合并心力衰竭患者的糖皮质激素治疗]
Rev Clin Esp. 2022 May;222(5):309-310. doi: 10.1016/j.rce.2021.11.002. Epub 2021 Nov 20.

本文引用的文献

1
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.COVID-19 住院患者中使用白细胞介素 6 拮抗剂与死亡率的关系：一项荟萃分析。
JAMA. 2021 Aug 10;326(6):499-518. doi: 10.1001/jama.2021.11330.
2
The use of remdesivir for the management of patients with moderate-to-severe COVID-19: a systematic review.瑞德西韦治疗中重度 COVID-19 患者的效果：一项系统评价。
Expert Rev Anti Infect Ther. 2022 Feb;20(2):211-229. doi: 10.1080/14787210.2021.1949984. Epub 2021 Jul 29.
3
Accelerating the Evolution of Severe Acute Respiratory Syndrome Coronavirus 2: A Risk of Combining Dexamethasone and Tocilizumab for Severe Coronavirus Disease 2019.加速严重急性呼吸综合征冠状病毒 2 的进化：将地塞米松和托珠单抗联合用于严重 2019 冠状病毒病的风险。
J Infect Dis. 2021 Sep 17;224(6):934-937. doi: 10.1093/infdis/jiab328.
4
Tocilizumab in COVID-19: The Cerrahpaşa-PREDICT score.托珠单抗治疗 COVID-19：Cerrahpaşa-PREDICT 评分。
J Infect Chemother. 2021 Sep;27(9):1329-1335. doi: 10.1016/j.jiac.2021.05.007. Epub 2021 May 12.
5
Corticosteroid Plus Tocilizumab in COVID-19: When Two Is Better Than One.皮质类固醇联合托珠单抗治疗新冠肺炎：两者联用优于单用。
Chest. 2021 May;159(5):2108-2109. doi: 10.1016/j.chest.2020.11.073.
6
Does methylprednisolone reduce the mortality risk in hospitalized COVID-19 patients? A meta-analysis of randomized control trials.甲泼尼龙是否降低住院 COVID-19 患者的死亡风险？一项随机对照试验的荟萃分析。
Expert Rev Respir Med. 2021 Aug;15(8):1049-1055. doi: 10.1080/17476348.2021.1925546. Epub 2021 Jul 2.
7
The effect of tocilizumab on mortality in hospitalized patients with COVID-19: a meta-analysis of randomized controlled trials.托珠单抗对 COVID-19 住院患者死亡率的影响：一项随机对照试验的荟萃分析。
Eur J Clin Pharmacol. 2021 Aug;77(8):1089-1094. doi: 10.1007/s00228-021-03087-z. Epub 2021 Feb 2.
8
Corticosteroid-related In-Hospital Hyperglycemia: Does It Negate Mortality Benefits in Coronavirus Disease 2019?皮质类固醇相关的院内高血糖：它是否会抵消2019冠状病毒病的死亡率益处？
Clin Infect Dis. 2021 Nov 2;73(9):e2848-e2849. doi: 10.1093/cid/ciaa1423.
9
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.COVID-19 重症患者全身使用皮质类固醇与死亡率的关联：一项荟萃分析。
JAMA. 2020 Oct 6;324(13):1330-1341. doi: 10.1001/jama.2020.17023.
10
Measurement of whole body interleukin-6 (IL-6) production: prediction of the efficacy of anti-IL-6 treatments.全身白细胞介素-6（IL-6）产生量的测量：抗IL-6治疗疗效的预测
Blood. 1995 Oct 15;86(8):3123-31.

IL-6 antagonists to replace systemic corticosteroids as the preferred anti-inflammatory therapy in patients with COVID-19?

作者信息

Kow Chia Siang, Zaihan Abdullah Faiz, Ramachandram Dinesh Sangarran, Hasan Syed Shahzad

机构信息

School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia; School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, Malaysia.

Department of Pharmacy, Shah Alam Hospital, Persiaran Kayangan, Seksyen 7, Shah Alam, Selangor, Malaysia.

出版信息

Cytokine. 2022 Jan;149:155730. doi: 10.1016/j.cyto.2021.155730. Epub 2021 Oct 5.

DOI:10.1016/j.cyto.2021.155730
PMID:34628129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8491934/
Abstract
摘要