Oak Ridge Institute for Science and Education (ORISE), USA; Biophysics and Biomedical Modeling Division, U.S. Army Research Institute of Environmental Medicine, USA.
Biophysics and Biomedical Modeling Division, U.S. Army Research Institute of Environmental Medicine, USA.
Comput Biol Med. 2021 Nov;138:104892. doi: 10.1016/j.compbiomed.2021.104892. Epub 2021 Sep 24.
This paper outlines the development of a finite element human thermoregulatory model using an anatomically and geometrically correct human body model. The finite element body model was constructed from digital Phantoms and is anatomically realistic, including 13 organs and tissues: skin, muscles, fat, bones, heart, lungs, brain, bladder, intestines, stomach, kidneys, liver, and eyes. The model simulates thermal responses through a passive and active system. The passive system describes heat balance within the body and between the skin surface and environment. The active system describes thermoregulatory mechanisms, i.e., vasodilation, vasoconstriction, sweating, and shivering heat production. This model predicts temperature distribution across the body at high spatial resolution, and provides insight into human thermoregulatory responses to non-uniform and transient environments. Predicted temperatures (i.e., core, skin, muscle and fat) at 29 sites were compared with measured values in comfort, hot, and cold conditions. The comprehensive validation shows predictions are accurate and acceptable.
本文概述了使用解剖学和几何上正确的人体模型开发有限元人体热调节模型的过程。该有限元体模型由数字体模构建,具有解剖学上的真实性,包括 13 个器官和组织:皮肤、肌肉、脂肪、骨骼、心脏、肺、脑、膀胱、肠、胃、肾脏、肝脏和眼睛。该模型通过被动和主动系统模拟热响应。被动系统描述了体内和皮肤表面与环境之间的热量平衡。主动系统描述了体温调节机制,即血管舒张、血管收缩、出汗和颤抖产热。该模型以高空间分辨率预测整个身体的温度分布,并深入了解人体对非均匀和瞬态环境的热调节反应。在舒适、炎热和寒冷条件下,将 29 个部位的预测温度(即核心、皮肤、肌肉和脂肪)与实测值进行了比较。综合验证表明预测结果准确且可接受。