Department of Pathology, University of Cambridge, UK.
Curr Opin Virol. 2021 Dec;51:106-110. doi: 10.1016/j.coviro.2021.09.010. Epub 2021 Oct 8.
The ability to establish long term persistent infection is a feature of human papillomaviruses. The available evidence is that this ability is a consequence of a complex local immune milieu whereby innate immune receptors and signalling pathway cascades are inhibited by HPV early proteins resulting in failure of dendritic cell maturation, antigen processing and presentation and activation of cytotoxic antigen specific T cell responses. The development of cutaneous and mucosal infection models with the mouse papillomavirus MmuPV1 and the access to multiple gene deficient strains is providing the frame work to dissect the mechanisms underlying these complex host virus interactions.
建立长期持续感染的能力是人类乳头瘤病毒的一个特征。现有证据表明，这种能力是复杂的局部免疫环境的结果，其中先天免疫受体和信号通路级联被 HPV 早期蛋白抑制，导致树突状细胞成熟、抗原加工和呈递以及细胞毒性抗原特异性 T 细胞反应的激活失败。使用小鼠乳头瘤病毒 MmuPV1 建立皮肤和粘膜感染模型以及获得多种基因缺失株为剖析这些复杂的宿主-病毒相互作用的机制提供了框架。
