MRC Cognition and Brain Sciences Unit, School of Clinical Medicine, University of Cambridge, Cambridge CB2 7EF, UK.
Psychology Department, Ashoka University 131029, India.
Cereb Cortex. 2022 Jun 7;32(12):2521-2537. doi: 10.1093/cercor/bhab362.
Recent functional MRI studies identified sensory-biased regions across much of the association cortices and cerebellum. However, their anatomical relationship to multiple-demand (MD) regions, characterized as domain-general due to their coactivation during multiple cognitive demands, remains unclear. For a better anatomical delineation, we used multimodal MRI techniques of the Human Connectome Project to scan subjects performing visual and auditory versions of a working memory (WM) task. The contrast between hard and easy WM showed strong domain generality, with essentially identical patterns of cortical, subcortical, and cerebellar MD activity for visual and auditory materials. In contrast, modality preferences were shown by contrasting easy WM with baseline; most MD regions showed visual preference while immediately adjacent to cortical MD regions, there were interleaved regions of both visual and auditory preference. The results may exemplify a general motif whereby domain-specific regions feed information into and out of an adjacent, integrative MD core.
最近的功能磁共振成像研究确定了整个联合皮层和小脑的感觉偏向区域。然而，它们与多需求（MD）区域的解剖关系仍然不清楚，这些区域由于在多个认知需求期间共同激活而被认为是领域通用的。为了更好地进行解剖划分，我们使用人类连接组计划的多模态 MRI 技术扫描了执行视觉和听觉工作记忆（WM）任务的受试者。硬 WM 和软 WM 的对比表现出很强的领域通用性，对于视觉和听觉材料，皮层、皮层下和小脑 MD 活动的模式基本相同。相比之下，通过将软 WM 与基线进行对比来显示模态偏好；大多数 MD 区域表现出对视觉的偏好，而在紧邻皮层 MD 区域的地方，有混合了视觉和听觉偏好的区域。这些结果可能是一个普遍的范例，即特定领域的区域将信息输入和输出到相邻的综合 MD 核心。
