Zhao Zhihong, Chen Yonggang, Ning Zhongping, Chen Xinhua
Department of Cardiology, Zhoupu Hospital, Shanghai University of Medical & Health Sciences, Shanghai, 201318.
Hangzhou Ruidi Biotechnology Co. Ltd., Hangzhou, 310003.
Zhongguo Yi Liao Qi Xie Za Zhi. 2021 Sep 30;45(5):517-523. doi: 10.3969/j.issn.1671-7104.2021.05.010.
Pulsed electric field(PEF) provides high-energy instantaneous pulse and release energy to myocardial cell membrane, resulting in irreversible electroporation and causes myocardial cell contents leakage, destruction of intracellular homeostasis, cell death, and slight inflammatory response. PEF as non-thermal energy promotes the design and application of arrhythmia ablation catheter to enter a new stage. There are currently limited clinical studies that have proved the safety and effectieness of Farawave PEF catheter, PVAC GOLD PEF catheter, Lattice-tip Sphere-9 PEF and radiofrequency (RF) catheter used for atrial fibrillation ablation, but still need further discussion. The research of atrial fibrillation ablation with PEF is under study in China. In this paper, the design and application of PEF ablation for tachyarrhythmia are reviewed.
脉冲电场（PEF）提供高能量瞬时脉冲并向心肌细胞膜释放能量，导致不可逆的电穿孔，引起心肌细胞内容物泄漏、细胞内稳态破坏、细胞死亡以及轻微的炎症反应。作为非热能的PEF推动了心律失常消融导管的设计与应用进入新阶段。目前仅有有限的临床研究证实了用于房颤消融的Farawave PEF导管、PVAC GOLD PEF导管、Lattice-tip Sphere-9 PEF导管以及射频（RF）导管的安全性和有效性，但仍需进一步探讨。中国正在开展关于PEF用于房颤消融的研究。本文对PEF消融治疗快速性心律失常的设计与应用进行综述。
