Hu Xincheng, Qu Hui, Wang Jizhe, Guo Yan, Yu Bo
Department of Otorhinolaryngology，the Second Hospital of Dalian Medical University，Dalian，116023，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Oct;35(10):920-924. doi: 10.13201/j.issn.2096-7993.2021.10.012.
To measure the normal value of nasal nitric oxide（nNO） concentration of 50 healthy adults in Dalian. By investigating the changing trend of nitric oxide accumulation concentration in the nasal cavity when changing the duration of nasal non-ventilation under quiet state, to provide ideas for the noninvasive detection of the concentration of nitric oxide in the sinus and the patency of the sinus ostium. ①The left and right nNO concentrations（LnNO, RnNO） of 50 healthy subjects in Dalian were measured by Sunvou-CA2122（Wuxi）, and the LnNO₁₀, LnNO₂₀, and LnNO₃₀ were measured through the left nasal cavity when the the time of nasal non ventilation was set for 10 s, 20 s, 30 s respectively. Ten subjects with good cooperation extended the time of nasal non ventilation to 50 s, and the measured nNO value was denoted as LnNO₅₀. ②Statistical analysis was performed by SPSS 19.0, and differences between two sides of nNO were analyzed by -test, and the trend of changes in concentration of NO accumulation in the nasal cavity when changing the duration of nasal nonventilation was investigated by One-way repeated measures ANOVA. ①The mean LnNO concentration in 50 healthy subjects was （383.32±126.35） ×10⁻⁹, the mean RnNO concentration was （395.26±124.32） ×10⁻⁹, and there was no significant difference between the two side（>0.05）, and the mean nNO was （389.29±124.85） ×10⁻⁹. ②The mean nNO concentration measured at 10, 20, and 30 seconds nasal nonventilation were （984.54±477.69） ×10⁻⁹ for LnNO₁₀, （1527.32±717.25） ×10⁻⁹ for LnNO₂₀, （2183.26±946.21） ×10⁻⁹ for LnNO₃₀, and（3083.00±1905.62） ×10⁻⁹ for LnNO₅₀ measured at prolonging nasal nonventilation time to 50 seconds for ten of these subjects; The difference in the presence of increased nNO concentrations measured after prolonged nasal nonventilation was statistically significant（<0.01）. ①The values of nNO of 50 healthy individuals in Dalian were（389.29±124.85） ×10⁻⁹. ②In healthy individuals, nNO can be measured unilaterally instead of bilaterally. ③In quiet condition, the duration of nasal nonventilation was prolonged for a certain period of time, and the nNO concentration showed a gradually increasing trend. It is expected to provide ideas for noninvasive detection of NO concentration in nasal sinuses and patency of nasal sinuses.
测量大连地区50名健康成年人鼻腔一氧化氮（nNO）浓度的正常值。通过研究安静状态下改变鼻腔非通气时间时鼻腔内一氧化氮蓄积浓度的变化趋势，为无创检测鼻窦内一氧化氮浓度及鼻窦开口通畅情况提供思路。①采用无锡的Sunvou - CA2122测量大连地区50名健康受试者的左右nNO浓度（LnNO、RnNO），当鼻腔非通气时间分别设定为10秒、20秒、30秒时，通过左侧鼻腔测量LnNO₁₀、LnNO₂₀和LnNO₃₀。10名配合良好的受试者将鼻腔非通气时间延长至50秒，测得的nNO值记为LnNO₅₀。②采用SPSS 19.0进行统计分析，nNO两侧差异采用t检验分析，改变鼻腔非通气时间时鼻腔内一氧化氮蓄积浓度的变化趋势采用单因素重复测量方差分析。①50名健康受试者的平均LnNO浓度为（383.32±126.35）×10⁻⁹，平均RnNO浓度为（395.26±124.32）×10⁻⁹，两侧差异无统计学意义（>0.05），平均nNO为（389.29±124.85）×10⁻⁹。②鼻腔非通气10秒、20秒和30秒时测得的平均nNO浓度，LnNO₁₀为（984.54±477.69）×10⁻⁹，LnNO₂₀为（1527.32±717.25）×10⁻⁹，LnNO₃₀为（2183.26±946.21）×10⁻⁹，其中10名受试者鼻腔非通气时间延长至50秒时测得的LnNO₅₀为（3083.00±1905.62）×l0⁻⁹；延长鼻腔非通气时间后测得的nNO浓度升高差异有统计学意义（<0.01）。①大连地区50名健康个体的nNO值为（389.29±124.85）×10⁻⁹。②在健康个体中，nNO可单侧测量而非双侧测量。③在安静状态下，鼻腔非通气时间延长一定时间，nNO浓度呈逐渐升高趋势。有望为无创检测鼻窦内NO浓度及鼻窦通畅情况提供思路。
