You Shaohua, Zhang Jing, Bai Yin, Ji Lingchao, Wang Hongtian
Department of Otolaryngology Head and Neck Surgery, People's Liberation Army General Hospital, Beijing 100853, China.
World J Otorhinolaryngol Head Neck Surg. 2016 Mar 19;2(1):22-27. doi: 10.1016/j.wjorl.2016.02.004. eCollection 2016 Mar.
To assess the normal levels of nasal nitric oxide (NNO) and fractional exhaled nitric oxide (FENO) in healthy Chinese young people, and to determine whether the obtained values were associated with age, sex, height, weight, BMI (body mass index) or BSA (body surface area).
One hundred and twenty healthy people were selected from a total of 436 Chinese young people based on their answers to a questionnaire. An electrochemical analyzer (NIOX MINO system) was used to measure NNO and FENO. The relationship between NNO, FENO and age, sex, height, weight, BMI, BSA was analyzed using SPSS software.
The values of NNO were normal distributed (mean 273.5 ppb; SD 112.3). The values of FENO were non-normally (Skewed) distributed (median: 14.00 ppb; interquartile range: 7.00 ppb). The obtained NNO values were independent of age, sex, height, weight, BMI and BSA, but were positively correlated to lnFENO (FENO log base e); lnFENO values were also independent of age, height, weight, BMI and BSA, but correlated with NNO and sex.
NNO values positively correlate with lnFENO in healthy people and the levels of each may be predicted by the other. The results of this study are expected to serve as a reference for future studies in China.
评估健康中国年轻人鼻腔一氧化氮（NNO）和呼出一氧化氮分数（FENO）的正常水平，并确定所获得的值是否与年龄、性别、身高、体重、体重指数（BMI）或体表面积（BSA）相关。
基于问卷回答，从436名中国年轻人中选出120名健康人。使用电化学分析仪（NIOX MINO系统）测量NNO和FENO。使用SPSS软件分析NNO、FENO与年龄、性别、身高、体重、BMI、BSA之间的关系。
NNO值呈正态分布（均值273.5 ppb；标准差112.3）。FENO值呈非正态（偏态）分布（中位数：14.00 ppb；四分位间距：7.00 ppb）。所获得的NNO值与年龄、性别、身高、体重、BMI和BSA无关，但与lnFENO（以e为底的FENO对数）呈正相关；lnFENO值也与年龄、身高、体重、BMI和BSA无关，但与NNO和性别相关。
健康人群中NNO值与lnFENO呈正相关，且两者水平可相互预测。本研究结果有望为中国未来的研究提供参考。
