系统评价和荟萃分析：α-肾上腺素能受体阻滞剂在慢性前列腺炎中的应用。

Systematic review and meta-analysis: α-adrenergic receptor blockers in chronic prostatitis.

机构信息

Department of Urology Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Ann Palliat Med. 2021 Sep;10(9):9870-9878. doi: 10.21037/apm-21-2160.

DOI:10.21037/apm-21-2160

PMID:34628913

Abstract

BACKGROUND

Prostatitis seriously endangers the health of men. While they have been widely used in recent years, there remains a lack of systematic evaluation of the clinical efficacy of α-receptor blockers (α-RBs)/α-adrenergic receptor blockers (α-ARBs) in its treatment. Based on this, this study was developed to systematically evaluate the clinical effect of α-ARB in the treatment of prostatitis.

METHODS

Randomized controlled trials (RCTs) studying α-RBs or α-ARBs, placebos, or other measures to treat prostatitis were searched in Cochrane Library, PubMed, Embase, and CBM databases from establishment to December 2020. The quality of included articles was evaluated using the Cochrane System Review Manual and Jadad tools, and a meta-analysis was performed using Review Manager 5.3 software.

RESULTS

A total of six articles meeting the requirements were found and included 450 patients. Meta-analysis showed that the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score [mean difference (MD) =-1.76, 95% confidence interval (CI): (-3.35 to -0.17), and P=0.03], pain score [MD =-2.24, 95% CI: (-3.65 to -0.83), and P=0.002], voiding symptom score [MD =-1.21, 95% CI: (-2.06 to -0.35), and P=0.006], and quality of life score [MD =-1.40, 95% CI: (-1.48 to -1.33), and P<0.00001] for patients in the experimental group were lower in contrast to those in the control group after the treatment.

DISCUSSION

The use of α-ARB could significantly improve the treatment effect of patients with prostatitis and improve their quality of life.

摘要

背景

前列腺炎严重危害男性健康。近年来，α-受体阻滞剂（α-RBs）/α-肾上腺素能受体阻滞剂（α-ARBs）在前列腺炎治疗中的应用较为广泛，但缺乏系统评价。基于此，本研究旨在系统评价 α-ARB 治疗前列腺炎的临床疗效。

方法

计算机检索 Cochrane Library、PubMed、Embase、CBM 数据库自建库至 2020 年 12 月，收集关于 α-RBs 或 α-ARBs 治疗前列腺炎的随机对照试验（RCT），采用 Cochrane 系统评价手册和 Jadad 量表评价纳入研究的质量，并采用 RevMan 5.3 软件进行 Meta 分析。

结果

共纳入 6 篇符合标准的文献，包含 450 例患者。Meta 分析结果显示，实验组患者的 NIH-CPSI 评分[均数差（MD）=-1.76，95%置信区间（CI）：（-3.35，-0.17），P=0.03]、疼痛评分[MD=-2.24，95%CI：（-3.65，-0.83），P=0.002]、排尿症状评分[MD=-1.21，95%CI：（-2.06，-0.35），P=0.006]和生活质量评分[MD=-1.40，95%CI：（-1.48，-1.33），P<0.00001]均低于对照组。