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三种药用部位的基本化学成分

The basic chemical substances of three medicinal parts from G. Don.

机构信息

Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

出版信息

Nat Prod Res. 2022 Sep;36(17):4498-4501. doi: 10.1080/14786419.2021.1986710. Epub 2021 Oct 11.

Abstract

G. Don belongs to Ericaceae family. As a toxic traditional Chinese medicine, its roots, flowers, and fruit are often mixed and substituted arbitrarily to treat rheumatoid arthritis in clinic. To clarify the main chemical basis of each medicinal part, and provide sufficient scientific basis for clinical application, analysis using HPLC-ELSD of the roots, flowers, and fruit from . was established, and characteristic chemical constituents of them were separated by tracking. The structures were determined by NMR methods. Finally, 16, 21, and 18 compounds were obtained from the roots, flowers, and fruit, respectively. Overall, 49 compounds were obtained, of which 25 were identified for the first time in . . Meanwhile, among the obtained compounds, 12, 11, and 6 characteristic peaks were identified from the roots, flowers, and fruit, respectively. Thus, the basic chemical substances of the medicinal parts of . were determined initially.

摘要

G. Don 属于杜鹃花科。作为一种有毒的中药,其根、花和果实经常被混合和任意替代,用于临床治疗类风湿关节炎。为了阐明各药用部位的主要化学成分,为临床应用提供充分的科学依据,建立了用 HPLC-ELSD 分析. 的根、花和果实的方法,并通过跟踪分离出它们的特征化学成分。通过 NMR 方法确定了它们的结构。最后,从根、花和果实中分别得到了 16、21 和 18 种化合物。总共得到了 49 种化合物,其中 25 种是首次在. 中鉴定得到的。同时,在所得到的化合物中,从根、花和果实中分别鉴定出 12、11 和 6 种特征峰。因此,初步确定了. 的药用部位的基本化学成分。

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