Llamas-Velasco M, Ovejero-Merino E, Salgado-Boquete L
Servicio de Dermatología, Hospital Universitario de la Princesa, Madrid, España.
Servicio de Cirugía General y Digestiva, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
Actas Dermosifiliogr. 2021 Jun;112(6):489-494. doi: 10.1016/j.ad.2020.12.001. Epub 2020 Dec 24.
Obesity is a major health problem whose well-known association with psoriasis has been amply described. The importance of obesity as a risk factor for poor prognosis in the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has recently been demonstrated. This review examines a possible relationship between obesity, psoriasis, and COVID-19, analyzing the pathophysiological links and their practical implications. On the one hand, a higher body mass index increases the risk of psoriasis and is also a factor in metabolic syndrome, which is common in patients with psoriasis and has been implicated in reducing the effectiveness of psoriasis treatments. On the other hand, obesity is a risk factor for severe COVID-19 and mortality. Obesity also promotes a proinflammatory state in the lung, where it compromises respiratory mechanics.
肥胖是一个主要的健康问题，其与银屑病之间广为人知的关联已有充分描述。肥胖作为严重急性呼吸综合征冠状病毒2感染所致2019冠状病毒病（COVID-19）预后不良的危险因素，其重要性最近已得到证实。本综述探讨肥胖、银屑病和COVID-19之间的可能关系，分析其病理生理联系及其实际意义。一方面，较高的体重指数会增加患银屑病的风险，也是代谢综合征的一个因素，代谢综合征在银屑病患者中很常见，并且与降低银屑病治疗效果有关。另一方面，肥胖是重症COVID-19和死亡的危险因素。肥胖还会促进肺部的促炎状态，损害呼吸力学。
