Macoir Joel, Martel-Sauvageau Vicent, Bouvier Liziane, Laforce Robert, Monetta Laura
Faculty of Medicine, Department of Rehabilitation, Laval University - Quebec, QC, Canada.
CERVO, Brain Research Centre - Quebec, QC, Canada.
Dement Neuropsychol. 2021 Jul-Sep;15(3):405-412. doi: 10.1590/1980-57642021dn15-030014.
The differential diagnosis of primary progressive aphasia (PPA) is challenging due to overlapping clinical manifestations of the different variants of the disease. This is particularly true for the logopenic variant of PPA (lvPPA), in which such overlap was reported with regard to impairments in repetition abilities. In this study, four individuals with lvPPA underwent standard neuropsychological and language assessments. The influence of psycholinguistic variables on their performance of in word, nonword and sentence repetition tasks was also specifically explored. Some level of heterogeneity was found in cognitive functions and in language. The four participants showed impairment in sentence repetition in which their performance was negatively affected by semantic reversibility and syntactic complexity. This study supports the heterogeneity of lvPPA with respect to the cognitive and linguistic status of participants. It also shows that sentence repetition is influenced not only by length, but also by semantic reversibility and syntactic complexity, two psycholinguistic variables known to place additional demands on phonological working memory.
原发性进行性失语（PPA）的鉴别诊断具有挑战性，因为该疾病不同变体的临床表现相互重叠。对于PPA的语音变异型（lvPPA）而言尤其如此，据报道，在重复能力受损方面存在这种重叠。在本研究中，四名患有lvPPA的个体接受了标准的神经心理学和语言评估。还特别探讨了心理语言学变量对他们在单词、非单词和句子重复任务表现的影响。在认知功能和语言方面发现了一定程度的异质性。这四名参与者在句子重复方面存在障碍，其中他们的表现受到语义可逆性和句法复杂性的负面影响。本研究支持了lvPPA在参与者认知和语言状态方面的异质性。它还表明，句子重复不仅受长度影响，还受语义可逆性和句法复杂性影响，这两个心理语言学变量已知会对语音工作记忆提出额外要求。
