Faculté de médecine, École des Sciences de la Réadaptation, Université Laval, Québec, QC, Canada.
Centre de recherche CERVO, Brain Research Centre, Québec, QC, Canada.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2024 Jul;31(4):723-741. doi: 10.1080/13825585.2023.2249198. Epub 2023 Aug 24.
The logopenic variant of primary progressive aphasia (lvPPA) is characterized mainly by anomia, production of phonological errors, and impairment in repetition of sentences. The functional origin of these language impairments is mainly attributed to the breakdown of phonological short-term memory. The present study examined the effects of phonological short-term memory impairment on language processing in lvPPA. In two studies, 11 participants with lvPPA and 11 healthy control participants were presented with repetition tasks in which the type and length of stimuli and the mode of administration were manipulated. Study 1 aimed to examine the influence of length and lexicality (words vs. pseudowords) on immediate and delayed repetition, whereas Study 2 aimed to examine the influence of length, syntactic complexity (nominalized vs. pronominalized sentences), and serial position on immediate sentence repetition. Study 1 showed that participants' performance with lvPPA was impaired only on immediate repetition of five-syllable pseudowords and on delayed repetition of words and pseudowords. Study 2 showed that participants' performance with lvPPA was impaired in the repetition of nominalized sentences where a recency effect was observed. Repetition of pronominalized sentences was also impaired in the lvPPA group. This study provides additional support for arguments regarding phonological short-term memory as a cause of language impairment in lvPPA. Clinically, the results of the study suggest that instruments for assessing repetition ability in lvPPA should include not only lists of short or long nominalized sentences, but also delayed repetition of words and pseudowords and pronominalized sentences.
主要以命名障碍、产生语音错误和句子重复障碍为特征的原发性进行性失语的 logopenic 变异型（lvPPA），其语言损伤的功能起源主要归因于语音短期记忆的破坏。本研究考察了语音短期记忆损伤对 lvPPA 语言处理的影响。在两项研究中，11 名 lvPPA 患者和 11 名健康对照者接受了重复任务，其中刺激的类型和长度以及呈现方式被操纵。研究 1 旨在考察长度和词汇性（单词与假词）对即时和延迟重复的影响，而研究 2 旨在考察长度、句法复杂性（名词化句与代词化句）和序列位置对即时句子重复的影响。研究 1 表明，lvPPA 患者的表现仅在即时重复五个音节的假词和延迟重复单词和假词时受到损害。研究 2 表明，lvPPA 患者在重复观察到近因效应的名词化句子时表现受损。代词化句子的重复在 lvPPA 组中也受损。本研究为语音短期记忆作为 lvPPA 语言损伤原因的论点提供了额外的支持。从临床角度来看，研究结果表明，评估 lvPPA 重复能力的工具不仅应包括短或长名词化句子的列表，还应包括单词和假词以及代词化句子的延迟重复。
