原发性进行性失语的分类：挑战与复杂性
Classification of primary progressive aphasia: challenges and complexities.
作者信息
Tippett Donna C
机构信息
Departments of Neurology, Otolaryngology - Head and Neck Surgery, and Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA.
出版信息
F1000Res. 2020 Jan 30;9. doi: 10.12688/f1000research.21184.1. eCollection 2020.
Abstract
Primary progressive aphasia (PPA) is classified into three variants, logopenic variant PPA (lvPPA), nonfluent agrammatic PPA (nfaPPA), and semantic variant PPA (svPPA), based on clinical (syndromic) characteristics with support from neuroimaging and/or underlying neuropathology. Classification of PPA variants provides information valuable to disease management. International consensus criteria are widely employed to identify PPA subtypes; however, classification is complex, and some individuals do not fit neatly into the subtyping scheme. In this review, diagnostic challenges and their implications are discussed, possible explanations for these challenges are explored, and approaches to address PPA classification are considered.
摘要
原发性进行性失语（PPA）根据临床（综合征）特征，在神经影像学和/或潜在神经病理学的支持下，分为三种变体：语音性变异型PPA（lvPPA）、非流利性语法缺失型PPA（nfaPPA）和语义性变异型PPA（svPPA）。PPA变体的分类为疾病管理提供了有价值的信息。国际共识标准被广泛用于识别PPA亚型；然而，分类很复杂，一些个体并不完全符合该亚型分类方案。在本综述中，讨论了诊断挑战及其影响，探讨了这些挑战的可能原因，并考虑了应对PPA分类的方法。
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