Levy M
Agents Actions Suppl. 1986;19:199-204.
When administered to humans, metamizol rapidly undergoes predominantly nonenzymatic biotransformation, yielding a vast number of active and later inactive metabolites. The biotransformational pathways and the clinical significance of the metabolites are discussed in the light of their individual pharmacokinetics.
当给人类使用时,安乃近迅速经历主要是非酶促的生物转化,产生大量活性及随后失活的代谢产物。根据其各自的药代动力学来讨论代谢产物的生物转化途径及其临床意义。