Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
The First People's Hospital of Neijiang, Sichuan, China.
Biomed Res Int. 2021 Sep 30;2021:6628923. doi: 10.1155/2021/6628923. eCollection 2021.
To assess the tear levels of inflammatory cytokines in patients with keratoconus (KC).
Systemic review and meta-analysis.
The following electronic databases and search engine were searched: PubMed, EMBASE, Web of Science, and Google Scholar. A systematic search of all relevant studies published through January 2021 was conducted, and the standardized mean difference (SMD) and 95% confidence interval (CI) of cytokine levels were calculated to estimate the pooled effects. Sensitivity analysis, subgroup analysis, and metaregression were applied to explore the sources of heterogeneity.
A total of 7 studies with 374 participants (374 eyes) from clinical studies were included. The tear levels of interleukin-1 beta (IL-1), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-) were significantly increased in KC compared with normal controls. The SMD of IL-1 was 1.93 (95% CI 0.22 to 3.65, = 0.03). The SMD of IL-6 was 1.22 (95% CI 0.59 to 1.84, < 0.001). The SMD of TNF- was 1.75 (95% CI 0.66 to 2.83, = 0.002). There was no significant difference between the two groups on interleukin-4 (IL-4) and interleukin-10 (IL-10). The SMD for IL-4 was 2.36 (95% CI -0.28 to 5.00, = 0.08) and for IL-10 was 0.30 (95% CI -1.29 to 1.89, = 0.71). Meta-regression analysis indicated that the heterogeneity maybe significantly correlated with the method of detection, the different ages, and the source of population.
Our meta-analysis demonstrated that proinflammatory cytokines IL-1, IL-6, and TNF- were increased, indicating that cytokine profile changed in KC tears and inflammation may play an important role in the pathogenesis and development of KC.
评估圆锥角膜（KC）患者的泪液中炎症细胞因子的水平。
系统综述和荟萃分析。
检索了以下电子数据库和搜索引擎：PubMed、EMBASE、Web of Science 和 Google Scholar。对截至 2021 年 1 月发表的所有相关研究进行了系统搜索，并计算了细胞因子水平的标准化均数差（SMD）和 95%置信区间（CI），以估计汇总效应。进行敏感性分析、亚组分析和荟萃回归分析以探讨异质性的来源。
纳入了 7 项来自临床研究的共 374 名参与者（374 只眼）的研究。与正常对照组相比，KC 患者的泪液中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的水平显著升高。IL-1 的 SMD 为 1.93（95%CI 0.22 至 3.65， = 0.03）。IL-6 的 SMD 为 1.22（95%CI 0.59 至 1.84， < 0.001）。TNF-α的 SMD 为 1.75（95%CI 0.66 至 2.83， = 0.002）。两组间白细胞介素-4（IL-4）和白细胞介素-10（IL-10）水平无显著差异。IL-4 的 SMD 为 2.36（95%CI -0.28 至 5.00， = 0.08），IL-10 的 SMD 为 0.30（95%CI -1.29 至 1.89， = 0.71）。荟萃回归分析表明，异质性可能与检测方法、不同年龄和人群来源显著相关。
我们的荟萃分析表明，促炎细胞因子 IL-1、IL-6 和 TNF-α升高，表明 KC 泪液中的细胞因子谱发生了变化，炎症可能在 KC 的发病机制和发展中发挥重要作用。
