Missiroli Sonia, Genovese Ilaria, Perrone Mariasole, Vezzani Bianca, Vitto Veronica A M, Giorgi Carlotta
Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.
J Clin Med. 2020 Mar 9;9(3):740. doi: 10.3390/jcm9030740.
The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell death and metabolism. However, recent scientific advances reveal that the intrinsic dynamicity of the mitochondrial compartment also plays a central role in proinflammatory signaling, identifying these organelles as a central platform for the control of innate immunity and the inflammatory response. Thus, mitochondrial dysfunctions have been related to severe chronic inflammatory disorders. Strategies aimed at reestablishing normal mitochondrial physiology could represent both preventive and therapeutic interventions for various pathologies related to exacerbated inflammation. Here, we explore the current understanding of the intricate interplay between mitochondria and the innate immune response in specific inflammatory diseases, such as neurological disorders and cancer.
线粒体通常具有的主要功能包括调节细胞增殖、产生三磷酸腺苷（ATP）、细胞死亡和新陈代谢。然而，最近的科学进展表明，线粒体区室的内在动态性在促炎信号传导中也起着核心作用，这表明这些细胞器是控制先天免疫和炎症反应的核心平台。因此，线粒体功能障碍与严重的慢性炎症性疾病有关。旨在重建正常线粒体生理功能的策略可能代表了针对各种与炎症加剧相关疾病的预防和治疗干预措施。在这里，我们探讨了目前对线粒体与特定炎症性疾病（如神经系统疾病和癌症）中先天免疫反应之间复杂相互作用的理解。
