Department of General Surgery II, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, PR China.
Department of Ophthalmology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, PR China.
Epigenomics. 2021 Oct;13(19):1557-1570. doi: 10.2217/epi-2021-0080. Epub 2021 Oct 11.
This study aimed to validate a combination of , and CA724 for gastric cancer (GC) detection. The performance of , and CA724 was examined in a prospective cohort study with 518 participants (151 with GC, 56 with atrophic gastritis, 87 with other gastrointestinal diseases and 224 with no evidence of disease). , or CA724 alone detected 48.3, 37.1 and 43.1% of GC, respectively. The combination of and detected 60.3% of GC, and the combination of all three markers detected 68.6% of GC. The detection sensitivity of and was significantly higher for gastric body and in elder subjects. was correlated with poorer GC survival. The combination of , and CA724 was adequately sensitive for GC detection. The blood was predictive for GC prognosis.
本研究旨在验证 、 和 CA724 联合用于胃癌（GC）检测的效果。我们在一项前瞻性队列研究中对 、 和 CA724 的性能进行了检测，该研究纳入了 518 名参与者（151 名 GC 患者、56 名萎缩性胃炎患者、87 名其他胃肠道疾病患者和 224 名无疾病证据的患者）。单独检测 、 和 CA724 可分别检测到 48.3%、37.1%和 43.1%的 GC。和 的联合检测可检测到 60.3%的 GC，而所有三种标志物的联合检测可检测到 68.6%的 GC。和 的检测敏感性在胃体部和老年患者中显著更高。与较差的 GC 生存相关。、和 CA724 的联合检测对 GC 检测具有足够的敏感性。血液标志物可预测 GC 的预后。
