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Diagnostic value of methylated SEPT9 and RNF180 for gastric cancer in high-risk population: a multi-centre retrospective study in Yunnan, Southwest China.

作者信息

Huang Ying, Yang Shu, Cun Yao, He Juying, Xu Guihua, Shi Pinghui, Yang Jinmei, Wang Qiang

机构信息

Mengzi People's Hospital, Mengzi, China.

Southern Central Hospital of Yunnan Province, Gejiu, China.

出版信息

Arch Med Sci. 2024 Dec 31;20(6):2077-2081. doi: 10.5114/aoms/196807. eCollection 2024.

DOI:10.5114/aoms/196807
PMID:39967944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11831321/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ed/11831321/598f39c423d1/AMS-20-6-196807-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ed/11831321/598f39c423d1/AMS-20-6-196807-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ed/11831321/598f39c423d1/AMS-20-6-196807-g001.jpg

相似文献

1
Diagnostic value of methylated SEPT9 and RNF180 for gastric cancer in high-risk population: a multi-centre retrospective study in Yunnan, Southwest China.甲基化SEPT9和RNF180在高危人群胃癌诊断中的价值：中国西南部云南的一项多中心回顾性研究
Arch Med Sci. 2024 Dec 31;20(6):2077-2081. doi: 10.5114/aoms/196807. eCollection 2024.
2
Circulating methylated Septin 9 and ring finger protein 180 for noninvasive diagnosis of early gastric cancer.循环甲基化Septin 9和环指蛋白180用于早期胃癌的无创诊断。
Transl Cancer Res. 2020 Nov;9(11):7012-7021. doi: 10.21037/tcr-20-1330.
3
Evaluating the clinical feasibility: The direct bisulfite genomic sequencing for examination of methylated status of E3 ubiquitin ligase RNF180 DNA promoter to predict the survival of gastric cancer.评估临床可行性：采用直接亚硫酸氢盐基因组测序法检测E3泛素连接酶RNF180 DNA启动子的甲基化状态以预测胃癌患者的生存期。
Cancer Biomark. 2015;15(3):259-65. doi: 10.3233/CBM-150466.
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Mediation of the malignant biological characteristics of gastric cancer cells by the methylated CpG islands in RNF180 DNA promoter.RNF180基因DNA启动子区甲基化CpG岛介导胃癌细胞的恶性生物学特性
Oncotarget. 2016 Jul 12;7(28):43461-43474. doi: 10.18632/oncotarget.9494.
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Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer.RNF180 基因结构、功能意义及其在胃癌中的临床应用的研究
Cancer. 2012 Feb 15;118(4):947-59. doi: 10.1002/cncr.26189. Epub 2011 Jun 29.
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Clinical and experimental role of ring finger protein 180 on lymph node metastasis and survival in gastric cancer.环状指蛋白 180 在胃癌淋巴结转移和生存中的临床和实验作用。
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Combining methylated RNF180 and SFRP2 plasma biomarkers for noninvasive diagnosis of gastric cancer.联合甲基化RNF180和SFRP2血浆生物标志物用于胃癌的无创诊断。
Transl Oncol. 2025 Jan;51:102190. doi: 10.1016/j.tranon.2024.102190. Epub 2024 Nov 13.
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Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer.RNF180启动子区域影响表达的高频甲基化位点的鉴定及其与胃癌预后的关系
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Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis.RNF180的启动子甲基化与幽门螺杆菌感染相关，并可作为胃癌和萎缩性胃炎的一个标志物。
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Diagnostic value of plasma RNF180 gene methylation for gastric cancer: A systematic review and meta-analysis.血浆RNF180基因甲基化对胃癌的诊断价值：一项系统评价和荟萃分析。
Front Oncol. 2023 Jan 10;12:1095101. doi: 10.3389/fonc.2022.1095101. eCollection 2022.

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Development and clinical applications of liquid biopsy assays in cancer screening.液体活检检测在癌症筛查中的发展与临床应用
Transl Cancer Res. 2025 Jun 30;14(6):3846-3859. doi: 10.21037/tcr-2025-272. Epub 2025 Jun 13.

本文引用的文献

1
Cell-free Nucleic Acid as Promising Diagnostic Biomarkers for Gastric Cancer: a Systematic Review.游离核酸作为胃癌有前景的诊断生物标志物：一项系统综述
J Cancer. 2024 Mar 25;15(10):2900-2912. doi: 10.7150/jca.92704. eCollection 2024.
2
A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening.基于无细胞游离 DNA 的血液检测用于结直肠癌筛查。
N Engl J Med. 2024 Mar 14;390(11):973-983. doi: 10.1056/NEJMoa2304714.
3
DNA methylation drives a new path in gastric cancer early detection: Current impact and prospects.DNA甲基化在胃癌早期检测中开辟新路径：当前影响与前景
Genes Dis. 2023 Mar 30;11(2):847-860. doi: 10.1016/j.gendis.2023.02.038. eCollection 2024 Mar.
4
Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer.联合甲基化SEPTIN9和RNF180血浆标志物用于胃癌的诊断和早期检测。
Cancer Commun (Lond). 2023 Nov;43(11):1275-1279. doi: 10.1002/cac2.12478. Epub 2023 Aug 16.
5
Plasma-Methylated SEPT9 for the Noninvasive Diagnosis of Gastric Cancer.用于胃癌无创诊断的血浆甲基化SEPT9
J Clin Med. 2022 Oct 29;11(21):6399. doi: 10.3390/jcm11216399.
6
Distinct Performance of Methylated in Upper and Lower Gastrointestinal Cancers and Combined Detection with Protein Markers.甲基化在上、下消化道癌症中的不同表现及与蛋白质标志物的联合检测
Genet Test Mol Biomarkers. 2022 Apr;26(4):239-248. doi: 10.1089/gtmb.2021.0127.
7
Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer.环状 RNA 作为非侵入性液体活检生物标志物用于早期胃癌检测的诊断效能。
Mol Cancer. 2022 Feb 9;21(1):42. doi: 10.1186/s12943-022-01527-7.
8
Circulating methylated Septin 9 and ring finger protein 180 for noninvasive diagnosis of early gastric cancer.循环甲基化Septin 9和环指蛋白180用于早期胃癌的无创诊断。
Transl Cancer Res. 2020 Nov;9(11):7012-7021. doi: 10.21037/tcr-20-1330.
9
A combination of methylation and protein markers is capable of detecting gastric cancer detection by combined markers.联合甲基化和蛋白质标志物的组合能够通过联合标志物检测胃癌。
Epigenomics. 2021 Oct;13(19):1557-1570. doi: 10.2217/epi-2021-0080. Epub 2021 Oct 11.
10
Gastric cancer.胃癌。
Lancet. 2020 Aug 29;396(10251):635-648. doi: 10.1016/S0140-6736(20)31288-5.