Departement of Nuclear Medicine, Kosin University Gospel Hospital, University of Kosin College of Medicine, Busan, Republic of Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea.
J Alzheimers Dis. 2021;84(3):1163-1172. doi: 10.3233/JAD-210722.
The association between dementia and serum adiponectin has been evaluated in many studies; however, conclusions remain mixed.
We investigated the cross-sectional associations of adiponectin with cognitive function and Alzheimer's disease (AD) biomarkers and whether serum adiponectin levels can predict cognitive outcomes.
This study included 496 participants from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) with available serum adiponectin levels at baseline and ≥65 years of age. Subjects were stratified based on sex and apolipoprotein ɛ4 (APOE4) carrier status to determine associations between adiponectin and cognitive function. The linear mixed model was used to analyze associations between adiponectin level and cognitive outcome in amnestic mild cognitive impairment (aMCI) patients.
Serum adiponectin levels were higher in aMCI and AD than in CN subjects among APOE4 non-carrier males (adiponectin in CN, aMCI, and AD: 0.54±0.24, 0.74±0.25, and 0.85±0.25, respectively, p < 0.001). In this group, serum adiponectin levels were associated with age (p = 0.001), ADAS13 (p < 0.001), memory function (p < 0.001), executive function (p < 0.001), total tau (p < 0.001), and phosphorylated tau (p < 0.001) measures in cerebrospinal fluid (CSF). Higher adiponectin level was not associated with cognitive outcome in aMCI patients in the linear mixed model analysis over 5.3±2.6 years of mean follow-up.
Serum adiponectin level was associated with cognitive function and CSF AD biomarkers among APOE4 non-carrier males. However, serum adiponectin level was not associated with longitudinal cognitive function outcome in aMCI.
许多研究评估了痴呆症与血清脂联素之间的关系，但结论仍存在分歧。
我们调查了脂联素与认知功能和阿尔茨海默病（AD）生物标志物的横断面关联，以及血清脂联素水平是否可以预测认知结果。
本研究纳入了来自阿尔茨海默病神经影像学倡议 1（ADNI1）的 496 名参与者，他们在基线时有可用的血清脂联素水平且年龄≥65 岁。根据性别和载脂蛋白 E4（APOE4）携带状态对受试者进行分层，以确定脂联素与认知功能之间的关系。线性混合模型用于分析在遗忘型轻度认知障碍（aMCI）患者中脂联素水平与认知结局之间的关系。
在 APOE4 非携带者男性中，与 CN 受试者相比，aMCI 和 AD 受试者的血清脂联素水平更高（CN、aMCI 和 AD 中的脂联素分别为 0.54±0.24、0.74±0.25 和 0.85±0.25，p<0.001）。在该组中，血清脂联素水平与年龄（p=0.001）、ADAS13（p<0.001）、记忆功能（p<0.001）、执行功能（p<0.001）、总 tau（p<0.001）和磷酸化 tau（p<0.001）有关脑脊液（CSF）中的测量值。在平均随访 5.3±2.6 年的线性混合模型分析中，较高的脂联素水平与 aMCI 患者的认知结局无关。
在 APOE4 非携带者男性中，血清脂联素水平与认知功能和 CSF AD 生物标志物有关。然而，血清脂联素水平与 aMCI 患者的纵向认知功能结局无关。
