Lin Jiali, Lei Langhuan, Liang Qiuyu, Huang Xiaozhi, Ding Yanping, Pan Liuxian, Yang Jianrong, Li Wei
Research Center of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Department of Health Management, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China.
Front Neurol. 2025 Apr 30;16:1395798. doi: 10.3389/fneur.2025.1395798. eCollection 2025.
Until recently, the association between circulating adiponectin (ADPN) levels and the risk of Alzheimer's disease (AD) and Parkinson's disease (PD) remained unclear.
We utilized public data from the IEU GWAS database to conduct a two-sample bidirectional Mendelian randomization (MR) analysis and multiple sensitivity analyses. The MR analysis was performed using the aggregated data, with the genetic risk score (GRS) serving as an instrumental variable.
The MR analyses revealed no significant causal association between genetically determined ADPN levels and the risk of AD (OR = 0.852, 95% confidence interval [CI]: 0.586-1.117, = 0.235) or PD (OR = 0.830, 95% CI: 0.780-1.156, = 0.606). Conversely, neither AD nor PD demonstrated any causal association with ADPN levels. The GRS approach yielded similar results ( > 0.05). However, it exhibited a negative correlation with interleukin 1β (IL1β, β = -0.31; 95% CI: -0.55 to -0.07, = 0.011). The Cochrane's Q test and MR-PRESSO analysis revealed no evidence of pleiotropy.
Our findings provide no evidence to substantiate a causal relationship between ADPN levels and the risk of AD and PD or vice versa. However, elevated levels of ADPN may correlate with lower levels of IL1β.
直到最近，循环脂联素（ADPN）水平与阿尔茨海默病（AD）和帕金森病（PD）风险之间的关联仍不明确。
我们利用IEU全基因组关联研究（GWAS）数据库的公开数据进行两样本双向孟德尔随机化（MR）分析和多项敏感性分析。MR分析使用汇总数据进行，基因风险评分（GRS）作为工具变量。
MR分析显示，基因决定的ADPN水平与AD风险（比值比[OR]=0.852，95%置信区间[CI]：0.586 - 1.117，P=0.235）或PD风险（OR = 0.830，95% CI：0.780 - 1.156，P = 0.606）之间无显著因果关联。相反，AD和PD与ADPN水平均无因果关联。GRS方法得出了类似结果（P>0.05）。然而，它与白细胞介素1β（IL1β，β = -0.31；95% CI：-0.55至-0.07，P = 0.011）呈负相关。Cochrane's Q检验和MR-PRESSO分析未发现多效性证据。
我们的研究结果没有证据证实ADPN水平与AD和PD风险之间存在因果关系，反之亦然。然而，ADPN水平升高可能与较低的IL1β水平相关。
