Gorodetskiĭ S I, Dyban A P, Vaĭsman B L, Golinskiĭ G F, Popkova G A
Biull Eksp Biol Med. 1986 Sep;102(9):339-42.
The human growth hormone gene, containing mouse metallothionein gene promotor, was injected into the male pronuclei of fertilized mouse ova. The progeny of transgenic mice included animals with both accelerated and inhibited growth. Radioimmunochemical analysis has revealed human growth hormone synthesis in both groups of transgenic mice. The molecular weight of the hormone synthesized in liver cells was 25,000 daltons. A possible mechanisms of foreign hormone effect on the growth of transgenic mice is discussed.
将含有小鼠金属硫蛋白基因启动子的人生长激素基因注入受精小鼠卵的雄原核中。转基因小鼠的后代包括生长加速和生长受抑制的动物。放射免疫化学分析表明，两组转基因小鼠均能合成人生长激素。肝细胞中合成的激素分子量为25,000道尔顿。文中讨论了外源激素影响转基因小鼠生长的可能机制。
