Cervantes F, Rozman C, Piera C, Fernandez M R
Blut. 1986 Oct;53(4):305-8. doi: 10.1007/BF00320889.
The iron status of 50 patients with Ph'-positive chronic granulocytic leukaemia (CGL) was evaluated at diagnosis by means of bone marrow and blood studies. A decreased or absent iron in semiquantitative estimation on bone marrow smears was observed in 92% of patients, and 88% had a low sideroblast score. In contrast, normal Hb and serum iron concentrations were found in the majority of cases, and only two out of the 50 patients displayed a decreased serum ferritin. To ascertain whether the bone marrow pattern of iron depletion could be due to an expansion of the red cell mass, the latter parameter was measured by isotopic methods in a subgroup of 11 patients. Normal or slightly increased values were obtained in all cases. We conclude that absent or decreased marrow iron is a common feature in the chronic phase of CGL, that generally does not reflect true iron deficiency. Since such a finding is also usual in polycythaemia vera and idiopathic myelofibrosis, it should be included among the features shared by the chronic myeloproliferative disorders.
通过骨髓和血液检查对50例Ph'阳性慢性粒细胞白血病（CGL）患者在诊断时的铁状态进行了评估。在92%的患者中观察到骨髓涂片半定量评估中铁减少或缺乏，88%的患者有低铁粒幼细胞评分。相比之下，大多数病例的血红蛋白和血清铁浓度正常，50例患者中只有2例血清铁蛋白降低。为了确定骨髓铁耗竭模式是否可能归因于红细胞量的增加，在11例患者的亚组中通过同位素方法测量了后一参数。所有病例均获得正常或略有升高的值。我们得出结论，骨髓铁缺乏或减少是CGL慢性期的常见特征，通常并不反映真正的缺铁。由于这一发现也常见于真性红细胞增多症和特发性骨髓纤维化，因此应将其纳入慢性骨髓增殖性疾病共有的特征之中。
