Cervantes F, Rozman C, Brugues R, Llanas I
Scand J Haematol. 1984 May;32(5):469-74. doi: 10.1111/j.1600-0609.1984.tb02187.x.
In 87 patients with Ph1 positive chronic granulocytic leukaemia (CGL), the bone marrow iron content was studied on smears obtained at diagnosis. A low sideroblast score and a decreased or absent marrow iron on semiquantitative estimation were found in 91% and 85% of cases, respectively. These findings did not correlate with blood parameters reflecting iron status such as Hb concentration, mean corpuscular volume, mean corpuscular haemoglobin, serum iron, total iron-binding capacity and transferrin saturation, which were normal in most cases. In 30 patients, initial serum ferritin was estimated, normal or slightly increased levels being as a rule found. In 24 of such patients, serum ferritin was again measured in remission following busulphan and, although values remained normal, a significant decrease was observed with respect to the initial levels (P less than 0.001). Thus, in spite of the consistent marrow pattern of iron depletion, initial iron stores appear to be normal in CGL. It seems, however, that the disease activity may partially influence the serum ferritin levels.
对87例Ph1阳性慢性粒细胞白血病（CGL）患者，在诊断时对骨髓涂片进行铁含量研究。分别在91%和85%的病例中发现幼红细胞铁粒评分低以及半定量评估时骨髓铁减少或缺乏。这些发现与反映铁状态的血液参数如血红蛋白浓度、平均红细胞体积、平均红细胞血红蛋白、血清铁、总铁结合力和转铁蛋白饱和度无关，大多数情况下这些参数均正常。对30例患者测定了初始血清铁蛋白，通常发现其水平正常或略有升高。在其中24例患者中，在白消安治疗后缓解期再次测定血清铁蛋白，尽管值仍正常，但与初始水平相比有显著下降（P小于0.001）。因此，尽管骨髓铁缺乏模式一致，但CGL患者的初始铁储备似乎正常。然而，疾病活动似乎可能部分影响血清铁蛋白水平。
