Dohendou Mohammad, Pakzad Khatereh, Nezafat Zahra, Nasrollahzadeh Mahmoud, Dekamin Mohammad G
Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Department of Chemistry, Faculty of Science, University of Qom, PO Box 37185-359, Qom, Iran.
Int J Biol Macromol. 2021 Dec 1;192:771-819. doi: 10.1016/j.ijbiomac.2021.09.162. Epub 2021 Oct 8.
Heck cross-coupling reaction (HCR) is one of the few transition metal catalyzed CC bond-forming reactions, which has been considered as the most effective, direct, and atom economical synthetic method using various catalytic systems. Heck reaction is widely employed in numerous syntheses including preparation of pharmaceutical and biologically active compounds, agrochemicals, natural products, fine chemicals, etc. Commonly, Pd-based catalysts have been used in HCR. In recent decades, the application of biopolymers as natural and effective supports has received attention due to their being cost effective, abundance, and non-toxicity. In fact, recent studies demonstrated that biopolymer-based catalysts had high sorption capacities, chelating activities, versatility, and stability, which make them potentially applicable as green materials (supports) in HCR. These catalytic systems present high stability and recyclability after several cycles of reaction. This review aims at providing an overview of the current progresses made towards the application of various polysaccharide and gelatin-supported metal catalysts in HCR in recent years. Natural polymers such as starch, gum, pectin, chitin, chitosan, cellulose, alginate and gelatin have been used as natural supports for metal-based catalysts in HCR. Diverse aspects of the reactions, different methods of preparation and application of polysaccharide and gelatin-based catalysts and their reusability have been reviewed.
赫克交叉偶联反应（HCR）是少数几种过渡金属催化的碳-碳键形成反应之一，它被认为是使用各种催化体系的最有效、直接且原子经济的合成方法。赫克反应广泛应用于众多合成领域，包括药物和生物活性化合物、农用化学品、天然产物、精细化学品等的制备。通常，钯基催化剂已被用于赫克交叉偶联反应。近几十年来，生物聚合物作为天然且有效的载体受到关注，因为它们具有成本效益、来源丰富且无毒。事实上，最近的研究表明，基于生物聚合物的催化剂具有高吸附容量、螯合活性、多功能性和稳定性，这使得它们有可能作为绿色材料（载体）应用于赫克交叉偶联反应。这些催化体系在经过几个反应循环后具有高稳定性和可回收性。本综述旨在概述近年来各种多糖和明胶负载金属催化剂在赫克交叉偶联反应中的应用进展。天然聚合物如淀粉、树胶、果胶、几丁质、壳聚糖、纤维素、藻酸盐和明胶已被用作赫克交叉偶联反应中金属基催化剂的天然载体。本文综述了该反应的各个方面、多糖和明胶基催化剂的不同制备方法和应用及其可重复使用性。
