Department of Biological Sciences, Quinnipiac University, Hamden, CT 06518, USA.
Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT 06473, USA.
Exp Gerontol. 2021 Nov;155:111585. doi: 10.1016/j.exger.2021.111585. Epub 2021 Oct 8.
Parkinson's disease (PD) is a progressive, age-associated neurodegenerative disorder that affects an estimated 10 million people worldwide. PD is characterized by proteinaceous, cytoplasmic inclusions containing α-synuclein, called Lewy Bodies, which form in dopaminergic neurons in an age-dependent manner, and are associated with the emergence of characteristic PD symptoms such as resting tremor, rigidity, slow movements and postural instability. Although considerable progress has been made in recent years in identifying genetic and environmental factors that are associated with PD, early diagnosis and therapeutic options remain severely lacking. Recently, microRNAs (miRNAs) have emerged as novel therapeutic targets in various diseases, such as cancer and neurodegenerative diseases. MiRNAs have been shown to play roles in various aging and neurodegenerative disease models across phyla. More recently, studies have identified specific roles for miRNAs and their targets in the pathogenesis and progression of PD in several model organisms. Here, we discuss the evolving field of miRNAs, their association with PD, and the outlook for the future.
帕金森病（PD）是一种进行性、与年龄相关的神经退行性疾病，估计全球有 1000 万人受到影响。PD 的特征是含有α-突触核蛋白的蛋白状、细胞质内含物，称为路易体，这些内含物以年龄依赖的方式在多巴胺能神经元中形成，并与特征性 PD 症状的出现有关，如静止性震颤、僵硬、运动缓慢和姿势不稳。尽管近年来在确定与 PD 相关的遗传和环境因素方面取得了相当大的进展，但早期诊断和治疗选择仍然严重缺乏。最近，microRNAs（miRNAs）作为各种疾病（如癌症和神经退行性疾病）的新型治疗靶点出现。miRNAs 已被证明在不同门的各种衰老和神经退行性疾病模型中发挥作用。最近的研究还确定了 miRNA 及其靶标在几种模型生物中 PD 发病机制和进展中的特定作用。在这里，我们讨论 miRNA 的不断发展的领域、它们与 PD 的关联以及未来的前景。
