Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, China.
Biosensors (Basel). 2022 Nov 24;12(12):1074. doi: 10.3390/bios12121074.
Neurodegenerative diseases manifest as progressive loss of neuronal structures and their myelin sheaths and lead to substantial morbidity and mortality, especially in the elderly. Despite extensive research, there are few effective treatment options for the diseases. MicroRNAs have been shown to be involved in the developmental processes of the central nervous system. Mounting evidence suggest they play an important role in the development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. However, there are few reviews regarding the roles of miRNAs in neurodegenerative diseases. This review summarizes the recent developments in the roles of microRNAs in neurodegenerative diseases and presents the application of microRNA-based methods in the early diagnosis of these diseases.
神经退行性疾病表现为神经元结构及其髓鞘的进行性丧失，导致发病率和死亡率显著升高，尤其是在老年人中。尽管进行了广泛的研究，但针对这些疾病的有效治疗方法却很少。microRNAs 已被证明参与中枢神经系统的发育过程。越来越多的证据表明，它们在阿尔茨海默病和帕金森病等神经退行性疾病的发生发展中起着重要作用。然而，关于 microRNAs 在神经退行性疾病中的作用的综述却很少。本文综述了 microRNAs 在神经退行性疾病中的作用的最新进展，并介绍了基于 microRNA 的方法在这些疾病的早期诊断中的应用。
