College of Veterinary Medicine, Huazhong Agricultural University, No.1 Shizishan Street, Wuhan, Hubei 430070, China.
College of Veterinary Medicine, Huazhong Agricultural University, No.1 Shizishan Street, Wuhan, Hubei 430070, China.
Res Vet Sci. 2021 Dec;141:4-13. doi: 10.1016/j.rvsc.2021.10.003. Epub 2021 Oct 7.
African swine fever (ASF) is an acute hemorrhagic disease caused by the infection of domestic swine and wild boar by the African swine fever virus (ASFV), with a mortality rate close to 90-100%. ASFV has been spreading in the world and poses a severe economic threat to the swine industry. There is no high effective vaccine commercially available or drug for this disease. However, attenuated ASFV isolates may infect pigs by chronic infection, and the infected pigs will not be lethal, which may indicate that pigs can produce protective immunity to resistant ASFV. Immunity acquisition and virus clearances are the central pillars to maintain the host normal cell activities and animal survival dependent on virus-host interactions, which has offered insights into the biology of ASFV. This review is organized around general themes including native immunity, endoplasmic reticulum stress, cell apoptosis, ubiquitination, autophagy regarding the intricate relationship between ASFV protein-host. Elucidating the multifunctional role of ASFV proteins in virus-host interactions can provide more new insights on the initial virus sensing, clearance, and cell homeostasis, and contribute to understanding viral pathogenesis and developing novel antiviral therapeutics.
非洲猪瘟（ASF）是由非洲猪瘟病毒（ASFV）感染家猪和野猪引起的急性出血性疾病，死亡率接近 90-100%。ASF 在世界范围内传播，对养猪业构成严重的经济威胁。目前尚无针对该疾病的高有效疫苗或药物。然而，减毒的 ASFV 分离株可能通过慢性感染感染猪，感染的猪不会致命，这可能表明猪可以对抵抗 ASFV 的产生保护免疫。免疫获得和病毒清除是维持宿主正常细胞活动和动物生存的核心支柱，这依赖于病毒-宿主相互作用，为 ASFV 的生物学提供了深入了解。本综述围绕天然免疫、内质网应激、细胞凋亡、泛素化、自噬等主题组织，讨论了 ASFV 蛋白与宿主之间复杂的关系。阐明 ASFV 蛋白在病毒-宿主相互作用中的多功能作用，可以为病毒初始感应、清除和细胞内稳态提供更多新的见解，并有助于理解病毒发病机制和开发新型抗病毒治疗方法。
