Ensembl COVID-19 资源：持续集成公共 SARS-CoV-2 数据。

The Ensembl COVID-19 resource: ongoing integration of public SARS-CoV-2 data.

机构信息

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

出版信息

Nucleic Acids Res. 2022 Jan 7;50(D1):D765-D770. doi: 10.1093/nar/gkab889.

DOI:10.1093/nar/gkab889

PMID:34634797

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8524594/

Abstract

The COVID-19 pandemic has seen unprecedented use of SARS-CoV-2 genome sequencing for epidemiological tracking and identification of emerging variants. Understanding the potential impact of these variants on the infectivity of the virus and the efficacy of emerging therapeutics and vaccines has become a cornerstone of the fight against the disease. To support the maximal use of genomic information for SARS-CoV-2 research, we launched the Ensembl COVID-19 browser; the first virus to be encompassed within the Ensembl platform. This resource incorporates a new Ensembl gene set, multiple variant sets, and annotation from several relevant resources aligned to the reference SARS-CoV-2 assembly. Since the first release in May 2020, the content has been regularly updated using our new rapid release workflow, and tools such as the Ensembl Variant Effect Predictor have been integrated. The Ensembl COVID-19 browser is freely available at https://covid-19.ensembl.org.

摘要

COVID-19 大流行见证了对 SARS-CoV-2 基因组测序的空前使用，用于流行病学跟踪和新兴变异株的鉴定。了解这些变异株对病毒感染力以及新兴治疗方法和疫苗功效的潜在影响，已成为抗击该疾病的基石。为了支持最大程度地利用基因组信息进行 SARS-CoV-2 研究，我们推出了 Ensembl COVID-19 浏览器；这是第一个包含在 Ensembl 平台中的病毒。该资源整合了一个新的 Ensembl 基因集、多个变异集，以及来自多个相关资源的注释，均与参考 SARS-CoV-2 组装对齐。自 2020 年 5 月首次发布以来，我们使用新的快速发布工作流程定期更新内容，并集成了 Ensembl Variant Effect Predictor 等工具。Ensembl COVID-19 浏览器可在 https://covid-19.ensembl.org 免费获得。