线粒体核糖体生物发生过程中催化核心的分层折叠
Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis.
作者信息
Lavdovskaia Elena, Hillen Hauke S, Richter-Dennerlein Ricarda
机构信息
Department of Cellular Biochemistry, University Medical Center Goettingen, D-37073 Goettingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Goettingen, D-37075 Goettingen, Germany.
Department of Cellular Biochemistry, University Medical Center Goettingen, D-37073 Goettingen, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Goettingen, D-37075 Goettingen, Germany; Research Group Structure and Function of Molecular Machines, Max Planck Institute for Biophysical Chemistry, D-37077 Goettingen, Germany.
出版信息
Trends Cell Biol. 2022 Mar;32(3):182-185. doi: 10.1016/j.tcb.2021.09.004. Epub 2021 Oct 8.
Final maturation steps during ribosome biogenesis require the assistance of assembly and quality control factors to ensure the folding of rRNA and proteins into a functional translation machinery. Here we integrate several recent structural snapshots of native large ribosomal subunit intermediates into the complex pathway of mitochondrial ribosome assembly.
核糖体生物合成过程中的最终成熟步骤需要组装和质量控制因子的协助，以确保核糖体RNA（rRNA）和蛋白质折叠成功能性翻译机器。在这里，我们将天然大核糖体亚基中间体的几个最新结构快照整合到线粒体核糖体组装的复杂途径中。
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