Wittmann D H, Kuipers T H, Fock R, Höll M, Bauernfeind A
Infection. 1986;14 Suppl 2:S130-7. doi: 10.1007/BF01647497.
The concentration of imipenem in organic bone, determined in 16 patients by bioassay after short infusion (15 min) of 1 g imipenem/cilastatin was 4.3 +/- 2.06 mg/kg (geometric mean +/- standard deviation, n = 13) after 45 minutes, and 2.8 +/- 1.86 mg/kg (n = 26) after 88 minutes. Imipenem penetrates into inorganic hydroxylapatite (imbution), however, its antimicrobial activity is lost. The mean serum concentration in 12 patients (mean age 77 years) with normal renal and hepatic function 15 minutes after the beginning of the infusion was 93.1 mg/l imipenem. The mean serum half life t (1/2 beta) was 1.32 hours, the total body clearance 108.6 1/h, and the volume of distribution during the beta phase V(beta) 12.4 1.
在16例患者中，静脉快速输注（15分钟）1克亚胺培南/西司他丁后，通过生物测定法测定的有机骨中亚胺培南浓度在45分钟时为4.3±2.06毫克/千克（几何平均数±标准差，n = 13），88分钟时为2.8±1.86毫克/千克（n = 26）。亚胺培南可渗入无机羟基磷灰石（吸附），但其抗菌活性丧失。12例肾功能和肝功能正常的患者（平均年龄77岁）在输注开始15分钟后的平均血清浓度为亚胺培南93.1毫克/升。平均血清半衰期t（1/2β）为1.32小时，全身清除率为108.6升/小时，β相分布容积V（β）为12.4升。
