N-甲酰亚胺基硫霉素（MK0787）的体外活性
In vitro activity of N-formimidoyl thienamycin (MK0787).
作者信息
Tally F P, Jacobus N V, Gorbach S L
出版信息
Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. doi: 10.1128/AAC.18.4.642.
Abstract
The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli, penicillin-resistant Staphylococcus aureus, enterococci, and anaerobic bacteria. The new derivative of thienamycin was more active than the parent compound, probably reflecting the stability of the analog.
摘要
硫霉素的稳定类似物N-甲脒基硫霉素（MK0787）的体外活性针对200种需氧菌和84种厌氧菌进行了测定。该化合物对耐药革兰氏阴性杆菌、耐青霉素金黄色葡萄球菌、肠球菌和厌氧菌具有高度活性。硫霉素的新衍生物比母体化合物更具活性，这可能反映了该类似物的稳定性。
相似文献
1
In vitro activity of N-formimidoyl thienamycin (MK0787).N-甲酰亚胺基硫霉素（MK0787）的体外活性
Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. doi: 10.1128/AAC.18.4.642.
2
In vitro activity of N-formimidoyl thienamycin (MK0787), a crystalline derivative of thienamycin.硫霉素的结晶衍生物N-甲脒基硫霉素（MK0787）的体外活性
Antimicrob Agents Chemother. 1980 Oct;18(4):557-61. doi: 10.1128/AAC.18.4.557.
3
Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics.一种新型稳定化硫霉素（N-甲脒基硫霉素）与其他抗生素相比的抗菌活性。
Antimicrob Agents Chemother. 1980 Jun;17(6):912-7. doi: 10.1128/AAC.17.6.912.
4
Susceptibilities of anaerobic bacteria to N-formimidoyl thienamycin (MK0787) and to other antibiotics.厌氧菌对N-甲酰亚胺基硫霉素（MK0787）及其他抗生素的敏感性。
Antimicrob Agents Chemother. 1982 Jun;21(6):1016-22. doi: 10.1128/AAC.21.6.1016.
5
N-formimidoyl thienamycin (MK0787): in vitro study.N-甲酰亚胺基硫霉素（MK0787）：体外研究。
Antimicrob Agents Chemother. 1981 Jan;19(1):201-4. doi: 10.1128/AAC.19.1.201.
6
Activity of N-formimidoyl thienamycin and cephalosporins against isolates from nosocomially acquired bacteremia.N-甲酰亚胺硫霉素和头孢菌素对医院获得性菌血症分离株的活性。
Antimicrob Agents Chemother. 1982 Mar;21(3):509-12. doi: 10.1128/AAC.21.3.509.
7
N-formimidoyl thienamycin (MK0787): in vitro activity against anaerobic bacteria.N-甲酰亚胺基硫霉素（MK0787）：对厌氧菌的体外活性
Antimicrob Agents Chemother. 1982 Jan;21(1):168-9. doi: 10.1128/AAC.21.1.168.
8
A comparison of the antibacterial activities of N-formimidoyl thienamycin (MK0787) with those of other recently developed beta-lactam derivatives.N-甲酰亚胺基硫霉素（MK0787）与其他近期研发的β-内酰胺衍生物抗菌活性的比较。
Antimicrob Agents Chemother. 1982 Aug;22(2):302-7. doi: 10.1128/AAC.22.2.302.
9
MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.MK0787（N-亚胺甲酰硫霉素）：体内外活性评估
Antimicrob Agents Chemother. 1980 Jun;17(6):993-1000. doi: 10.1128/AAC.17.6.993.
10
In vitro evaluation of N-formimidoyl thienamycin (MK0787) combined with amikacin against gram-negative bacilli and Staphylococcus aureus.N-甲酰亚胺硫霉素（MK0787）联合阿米卡星对革兰氏阴性杆菌和金黄色葡萄球菌的体外评价
Antimicrob Agents Chemother. 1982 Dec;22(6):1064-6. doi: 10.1128/AAC.22.6.1064.
引用本文的文献
1
Imipenem and meropenem: Comparison of in vitro activity, pharmacokinetics, clinical trials and adverse effects.亚胺培南和美罗培南：体外活性、药代动力学、临床试验及不良反应的比较
Can J Infect Dis. 1998 Jul;9(4):215-28. doi: 10.1155/1998/831425.
2
In vitro activity of new beta-lactam antibiotics and other antimicrobial drugs against anaerobic isolates from obstetric and gynecological infections.新型β-内酰胺类抗生素及其他抗菌药物对妇产科感染分离出的厌氧菌的体外活性
Antimicrob Agents Chemother. 1982 Oct;22(4):711-4. doi: 10.1128/AAC.22.4.711.
3
Comparative activities of 13 beta-lactam antibiotics.13种β-内酰胺类抗生素的比较活性
Antimicrob Agents Chemother. 1982 Jun;21(6):925-34. doi: 10.1128/AAC.21.6.925.
4
Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis.N-甲酰亚胺硫霉素在实验性大肠杆菌脑膜炎中的药代动力学及细菌学疗效
Antimicrob Agents Chemother. 1982 Mar;21(3):390-2. doi: 10.1128/AAC.21.3.390.
5
Lack of in vivo and in vitro bactericidal activity of N-formimidoyl thienamycin against enterococci.N-甲酰亚胺硫霉素对肠球菌缺乏体内和体外杀菌活性。
Antimicrob Agents Chemother. 1982 Sep;22(3):448-52. doi: 10.1128/AAC.22.3.448.
6
Susceptibilities of anaerobic bacteria to N-formimidoyl thienamycin (MK0787) and to other antibiotics.厌氧菌对N-甲酰亚胺基硫霉素（MK0787）及其他抗生素的敏感性。
Antimicrob Agents Chemother. 1982 Jun;21(6):1016-22. doi: 10.1128/AAC.21.6.1016.
7
Activity of N-formimidoyl thienamycin and cephalosporins against isolates from nosocomially acquired bacteremia.N-甲酰亚胺硫霉素和头孢菌素对医院获得性菌血症分离株的活性。
Antimicrob Agents Chemother. 1982 Mar;21(3):509-12. doi: 10.1128/AAC.21.3.509.
8
N-formimidoyl thienamycin (MK0787): in vitro activity against anaerobic bacteria.N-甲酰亚胺基硫霉素（MK0787）：对厌氧菌的体外活性
Antimicrob Agents Chemother. 1982 Jan;21(1):168-9. doi: 10.1128/AAC.21.1.168.
9
In vitro activity of N-formimidoyl thienamycin and other beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus.N-甲脒硫霉素及其他β-内酰胺类抗生素对耐甲氧西林金黄色葡萄球菌的体外活性
Antimicrob Agents Chemother. 1982 Feb;21(2):341-3. doi: 10.1128/AAC.21.2.341.
10
In vitro evaluation of N-formimidoyl thienamycin (MK0787) combined with amikacin against gram-negative bacilli and Staphylococcus aureus.N-甲酰亚胺硫霉素（MK0787）联合阿米卡星对革兰氏阴性杆菌和金黄色葡萄球菌的体外评价
Antimicrob Agents Chemother. 1982 Dec;22(6):1064-6. doi: 10.1128/AAC.22.6.1064.
本文引用的文献
1
MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.MK0787（N-亚胺甲酰硫霉素）：体内外活性评估
Antimicrob Agents Chemother. 1980 Jun;17(6):993-1000. doi: 10.1128/AAC.17.6.993.
2
In vitro activity of thienamycin.硫霉素的体外活性。
Antimicrob Agents Chemother. 1978 Sep;14(3):436-8. doi: 10.1128/AAC.14.3.436.
3
Inactivation of cephalosporins by Bacteroides.拟杆菌对头孢菌素的灭活作用。
Antimicrob Agents Chemother. 1979 Nov;16(5):565-71. doi: 10.1128/AAC.16.5.565.
4
In vitro activity of LY127935.LY127935的体外活性。
Antimicrob Agents Chemother. 1979 Sep;16(3):287-92. doi: 10.1128/AAC.16.3.287.
Zotero 插件