长链非编码RNA：隐藏在癌症信号网络中的微调器。

Zhao Shanshan, Zhang Xue, Chen Shuo, Zhang Song

Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of Liaoning Province, Reproductive Medicine Center, Obstetrics and Gynecology Department, Shengjing Hospital Affiliated to China Medical University, 110022, Shenyang, Liaoning, China.

Department of Epigenetics, China Medical University, 110122, Shenyang, Liaoning, China.

Cell Death Discov. 2021 Oct 11;7(1):283. doi: 10.1038/s41420-021-00678-8.

With the development of sequencing technology, a large number of long non-coding RNAs (lncRNAs) have been identified in addition to coding genes. LncRNAs, originally considered as junk RNA, are dysregulated in various types of cancer. Although protein-coding signaling pathways underlie various biological activities, and abnormal signal transduction is a key trigger and indicator for tumorigenesis and cancer progression, lncRNAs are sparking keen interest due to their versatile roles in fine-tuning signaling pathways. We are just beginning to scratch the surface of lncRNAs. Therefore, despite the fact that lncRNAs drive malignant phenotypes from multiple perspectives, in this review, we focus on important signaling pathways modulated by lncRNAs in cancer to demonstrate an up-to-date understanding of this emerging field.

随着测序技术的发展，除了编码基因之外，还鉴定出了大量的长链非编码RNA（lncRNA）。lncRNA最初被认为是垃圾RNA，在各种类型的癌症中表达失调。尽管蛋白质编码信号通路是各种生物学活性的基础，并且异常信号转导是肿瘤发生和癌症进展的关键触发因素和指标，但lncRNA因其在微调信号通路中的多种作用而引发了人们的浓厚兴趣。我们对lncRNA的了解才刚刚开始。因此，尽管lncRNA从多个角度驱动恶性表型，但在本综述中，我们重点关注lncRNA在癌症中调节的重要信号通路，以展示对这一新兴领域的最新认识。