Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China.
Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, TECHMED Centre, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands.
J Mater Chem B. 2021 Nov 3;9(42):8718-8738. doi: 10.1039/d1tb01771c.
Currently, the therapeutic performance of traditional mono-chemotherapy on cancers remains unsatisfactory because of the tumor heterogeneity and multidrug resistance. In light of intricate tumor structures and distinct tumor microenvironments (TMEs), combinational therapeutic strategies with multiple anticancer drugs from different mechanisms can synergistically optimize the outcomes and concomitantly minimize the adverse effects during the therapy process. Extensive research on polymeric micelles (PMs) for biomedical applications has revealed the growing importance of nanomedicines for cancer therapy in the recent decade. Starting from traditional simple delivery systems, PMs have been extended to multi-faceted therapeutic strategies. Here we review and summarize the most recent advances in combinational therapy based on multifunctional PMs including a combination of multiple anticancer drugs, chemo-gene therapy, chemo-phototherapy and chemo-immunotherapy. The design approaches, action mechanisms and therapeutic applications of these nanodrugs are summarized. In addition, we highlight the opportunities and potential challenges associated with this promising field, which will provide new guidelines for advanced combinational cancer chemotherapy.
目前，由于肿瘤异质性和多药耐药性，传统单一化疗药物的治疗效果仍不尽人意。鉴于复杂的肿瘤结构和不同的肿瘤微环境（TMEs），来自不同机制的多种抗癌药物联合治疗策略可以协同优化治疗效果，并在治疗过程中同时最小化不良反应。近年来，人们对用于生物医学应用的聚合物胶束（PMs）进行了广泛研究，这凸显了纳米药物在癌症治疗中的重要性。从传统的简单递送系统开始，PM 已经扩展到多方面的治疗策略。在这里，我们综述并总结了基于多功能 PM 的联合治疗的最新进展，包括多种抗癌药物的联合、化疗-基因治疗、化疗-光疗和化疗-免疫治疗。总结了这些纳米药物的设计方法、作用机制和治疗应用。此外，我们还强调了该领域面临的机遇和潜在挑战，这将为先进的联合癌症化疗提供新的指导。
