Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University (SYSU), No 600, Tianhe Road, Guangzhou, 510630, Guangdong, People's Republic of China.
Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Abdom Radiol (NY). 2022 Jan;47(1):399-408. doi: 10.1007/s00261-021-03302-6. Epub 2021 Oct 11.
To demonstrate the feasibility and diagnostic value of high-frequency magnetic resonance elastography (MRE) for evaluation of prostatic disease in patients with lower urinary tract symptoms (LUTS).
41 patients who underwent preoperative prostate MRI and MRE with a modified driver were enrolled retrospectively from May 2016 to September 2021. All were included in the assessment of MRE image quality, using a qualitative visual inspection and a quantitative confidence map. 35 patients (prostate cancer (PCa), n = 13; non-PCa, n = 22) undergoing prostatectomy or biopsy were evaluated for the diagnostic performance of stiffness values. The confidence values and the stiffness values were analyzed by one-way analysis of variance (ANOVA) and independent samples T test, respectively. Area under the receiver operating characteristic (AUROC) analysis was performed.
Through the qualitative analysis, all MRE acquisitions were successful at 60, 90, 120 and 150 Hz. The quantitative confidence values were significantly lower at 60 Hz (0.683 ± 0.055) and 90 Hz (0.762 ± 0.048) than that at 120 Hz (0.814 ± 0.049) and 150 Hz (0.840 ± 0.049), all P < 0.001. The stiffness of PCa was higher than non-PCa at 90 Hz (P = 0.008), 120 Hz (P < 0.001) and 150 Hz (P < 0.001). The AUCs were 0.773, 0.881 and 0.944, respectively.
Prostate MRE using the modified driver is feasible at 60-150 Hz and image quality is better at higher frequencies. Prostate MRE may be useful and helpful to evaluate prostate diseases in patients with LUTS at higher frequencies; however, further study may be warranted with larger population in future.
展示高频磁共振弹性成像（MRE）在评估下尿路症状（LUTS）患者前列腺疾病中的可行性和诊断价值。
回顾性纳入 2016 年 5 月至 2021 年 9 月期间接受改良驱动器术前前列腺 MRI 和 MRE 的 41 例患者。所有患者均进行 MRE 图像质量评估，包括定性视觉检查和定量置信图。对 35 例（前列腺癌（PCa），n=13；非 PCa，n=22）接受前列腺切除术或活检的患者进行硬度值的诊断性能评估。采用单因素方差分析（ANOVA）和独立样本 t 检验分别对置信值和硬度值进行分析。采用受试者工作特征（ROC）曲线分析评估曲线下面积（AUROC）。
通过定性分析，所有 MRE 采集在 60、90、120 和 150 Hz 下均成功。定量置信值在 60 Hz（0.683±0.055）和 90 Hz（0.762±0.048）显著低于 120 Hz（0.814±0.049）和 150 Hz（0.840±0.049），均 P<0.001。90 Hz（P=0.008）、120 Hz（P<0.001）和 150 Hz（P<0.001）时 PCa 的硬度高于非 PCa。AUC 分别为 0.773、0.881 和 0.944。
使用改良驱动器的前列腺 MRE 在 60-150 Hz 下是可行的，且在更高频率下图像质量更好。前列腺 MRE 可能在更高频率下对评估 LUTS 患者的前列腺疾病有用且有帮助，但未来可能需要更大的人群进行进一步研究。
