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非特殊型浸润性乳腺癌伴髓样模式：形态学和免疫组织化学特征。

Invasive Breast Carcinoma of No Special Type with Medullary Pattern: Morphological and Immunohistochemical Features.

机构信息

Department of Pathology, Medical Institute, Sumy State University, SUMY, UKRAINE.

出版信息

Turk Patoloji Derg. 2022;38(3):205-212. doi: 10.5146/tjpath.2021.01559.

DOI:10.5146/tjpath.2021.01559
PMID:34636027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10508404/
Abstract

OBJECTIVE

Our study investigated the morphological and immunohistochemical characteristics of invasive breast carcinoma of no special type (IBC-NST) with medullary pattern to explore the inconsistencies between the structural and clinical traits of this category of tumor.

MATERIAL AND METHOD

The breast carcinoma samples (n = 26) with medullary pattern (defined according to established criteria) were subjected to immunohistochemical assays of the following receptors: ER, PR, HER2/neu, Ki-67, p53, Bcl-2, VEGF, MMP1, E-cadherin, EGFR, Hsp70, Hsp90, CD20, CD3, CD4, CD8, CD68, CD163, CD56, CD138, MPO, S100, IgG, IgM, and PD-L1.

RESULTS

IBC-NST with medullary pattern was found to have negative expression of ER, PR, and HER2/neu; strong positive expression of Kі-67, mutant р53, Bcl-2, E-cadherin, EGFR, and PD-L1; moderate positive expression of Hsp70 and Hsp90; and low or negative expression of VEGF and MMP1. Furthermore, there was pronounced variability in the qualitative composition of tumor immune infiltrates with regards to T-lymphocytes, B-lymphocytes, macrophages, plasmocytes, and granulocytes.

CONCLUSION

IBC-NST with medullary pattern has many unfavourable morphological and immunohistochemical prognostic characteristics, which are balanced against the pronounced protective properties of the tumor cells and the qualitative characteristics of the tumor microenvironment. These can lead to a favourable disease course despite the relatively adverse features of the carcinoma cells.

摘要

目的

本研究调查了特殊类型浸润性乳腺癌（IBC-NST）伴髓样模式的形态学和免疫组织化学特征，以探讨此类肿瘤的结构和临床特征之间的不一致性。

材料和方法

根据既定标准，对具有髓样模式的乳腺癌样本（n=26）进行以下受体的免疫组织化学检测：ER、PR、HER2/neu、Ki-67、p53、Bcl-2、VEGF、MMP1、E-cadherin、EGFR、Hsp70、Hsp90、CD20、CD3、CD4、CD8、CD68、CD163、CD56、CD138、MPO、S100、IgG、IgM 和 PD-L1。

结果

发现 IBC-NST 伴髓样模式的 ER、PR 和 HER2/neu 表达阴性；Kі-67、突变 p53、Bcl-2、E-cadherin、EGFR 和 PD-L1 强阳性表达；Hsp70 和 Hsp90 中度阳性表达；VEGF 和 MMP1 低或阴性表达。此外，肿瘤免疫浸润的定性组成在 T 淋巴细胞、B 淋巴细胞、巨噬细胞、浆细胞和粒细胞方面存在显著的可变性。

结论

IBC-NST 伴髓样模式具有许多不良的形态学和免疫组织化学预后特征，但肿瘤细胞具有明显的保护特性和肿瘤微环境的定性特征，这使得尽管癌细胞具有相对不利的特征，但疾病过程仍可能良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/0632c4e3a45d/TurkPatolojiDerg-38-10969-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/814ff1621424/TurkPatolojiDerg-38-10969-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/23f067e3b2fc/TurkPatolojiDerg-38-10969-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/ddaad26a5934/TurkPatolojiDerg-38-10969-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/1079da5bfab7/TurkPatolojiDerg-38-10969-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/0632c4e3a45d/TurkPatolojiDerg-38-10969-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/814ff1621424/TurkPatolojiDerg-38-10969-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/23f067e3b2fc/TurkPatolojiDerg-38-10969-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/ddaad26a5934/TurkPatolojiDerg-38-10969-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/1079da5bfab7/TurkPatolojiDerg-38-10969-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4186/10508404/0632c4e3a45d/TurkPatolojiDerg-38-10969-g005.jpg

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本文引用的文献

1
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CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
2
The 2019 World Health Organization classification of tumours of the breast.《2019年世界卫生组织乳腺肿瘤分类》
Histopathology. 2020 Aug;77(2):181-185. doi: 10.1111/his.14091. Epub 2020 Jul 29.
3
Tumor-Associated Macrophages as Potential Prognostic Biomarkers of Invasive Breast Cancer.
子宫子宫内膜样腺癌组织学和免疫组化特征中微血管密度的关系：实验研究
Ann Med Surg (Lond). 2023 Jun 13;85(7):3461-3468. doi: 10.1097/MS9.0000000000000939. eCollection 2023 Jul.
肿瘤相关巨噬细胞作为浸润性乳腺癌潜在的预后生物标志物
J Breast Cancer. 2019 Mar;22(1):38-51. doi: 10.4048/jbc.2019.22.e5.
4
[Not Available].[无可用内容]。
Maedica (Bucur). 2018 Dec;13(4):317-320. doi: 10.26574/maedica.2018.13.4.317.
5
Understanding the tumor immune microenvironment (TIME) for effective therapy.理解肿瘤免疫微环境（TIME）以实现有效的治疗。
Nat Med. 2018 May;24(5):541-550. doi: 10.1038/s41591-018-0014-x. Epub 2018 Apr 23.
6
The Prognostic Significance of Hsp70/Hsp90 Expression in Breast Cancer: A Systematic Review and Meta-analysis.热休克蛋白70/热休克蛋白90表达在乳腺癌中的预后意义：一项系统评价与Meta分析
Anticancer Res. 2018 Mar;38(3):1551-1562. doi: 10.21873/anticanres.12384.
7
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8
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9
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