Talebi Marjan, Talebi Mohsen, Farkhondeh Tahereh, Simal-Gandara Jesus, Kopustinskiene Dalia M, Bernatoniene Jurga, Pourbagher-Shahri Ali Mohammad, Samarghandian Saeed
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran.
Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, 76019, USA.
Curr Drug Targets. 2022;23(5):458-470. doi: 10.2174/1389450122666211005113234.
Cardiometabolic diseases (CMD) have caused a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis. They have interlinked pathways, interacting and interconnecting with each other. The natural flavonoid chrysin has been shown to possess a broad spectrum of therapeutic activities for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorders. Studies have shown that chrysin protects the cardiovascular system by enhancing the intrinsic antioxidative defense system. This antioxidant property enhanced by chrysin protects against several risk factors of cardiometabolic disorders, including atherosclerosis, vascular inflammation and dysfunction, platelet aggregation, hypertension, dyslipidemia, cardiotoxicity, myocardial infarction, injury, and remodeling, diabetes-induced injuries, and obesity. Chrysin also exhibited anti-inflammatory mechanisms through inhibiting pro-inflammatory pathways, including NF-κB, MAPK, and PI3k/Akt. Furthermore, chrysin modulated NO, RAS, AGE/RAGE, and PPARs pathways which contributed to the risk factors of cardiometabolic disorders. Taken together, the mechanisms in which chrysin protects against cardiometabolic disorder are more than merely antioxidation and anti-inflammation in the cardiovascular system.
心脏代谢疾病（CMD）在全球范围内造成了巨大的发病和死亡负担。CMD的恶性循环包括II型糖尿病、高血压、血脂异常、肥胖和动脉粥样硬化。它们具有相互关联的途径，相互作用并相互连接。天然黄酮类化合物白杨素已被证明对人类健康具有广泛的治疗活性。在此，我们对白杨素对心脏代谢紊乱的心脏保护新机制进行了深入研究。研究表明，白杨素通过增强内在抗氧化防御系统来保护心血管系统。白杨素增强的这种抗氧化特性可抵御心脏代谢紊乱的多种危险因素，包括动脉粥样硬化、血管炎症和功能障碍、血小板聚集、高血压、血脂异常、心脏毒性、心肌梗死、损伤和重塑、糖尿病引起的损伤以及肥胖。白杨素还通过抑制包括NF-κB、MAPK和PI3k/Akt在内的促炎途径表现出抗炎机制。此外，白杨素调节了与心脏代谢紊乱危险因素相关的NO、RAS、AGE/RAGE和PPARs途径。综上所述，白杨素预防心脏代谢紊乱的机制不仅仅是心血管系统中的抗氧化和抗炎作用。
