Farkhondeh Tahereh, Samarghandian Saeed, Bafandeh Fereshteh
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Noncommunicable Diseases Research Center, University of Medical Sciences, Neyshabur, Iran.
Cardiovasc Hematol Agents Med Chem. 2019;17(1):17-27. doi: 10.2174/1871525717666190114145137.
Chrysin is one of the flavonoids fruits, vegetables, and plant especially found in honey, it has been indicated that its cardiovascular protective effect is due to its antioxidative effects and anti inflammatory activities. Chrysin exerts an antioxidant effect by enhancing the antioxidant system, suppressing pro-oxidant enzymes, scavenging free radicals and chelating redox active transition metal ions. Chrysin decreases lipid synthesis and also increases its metabolism, thereby ameliorating blood lipid profile. Chrysin modulates vascular function by increasing the bioavailability of endothelial nitric oxide. Chrysin inhibits the development of atherosclerosis by decreasing vascular inflammation. The anti-inflammatory effects of chrysin may relate to its inhibitory effect on the nuclear transcriptional factor-kB signaling pathway. It also prevents vascular smooth muscle cells proliferation and thrombogenesis. Altogether, chrysin may be effective as a natural agent for the prevention and treatment of cardiovascular diseases; however, several clinical trial studies should be done to confirm its protective effects on humans.
白杨素是一种存在于水果、蔬菜和植物中的黄酮类化合物，尤其在蜂蜜中含量丰富。研究表明，其心血管保护作用归因于抗氧化作用和抗炎活性。白杨素通过增强抗氧化系统、抑制促氧化酶、清除自由基以及螯合具有氧化还原活性的过渡金属离子来发挥抗氧化作用。白杨素可减少脂质合成并增加其代谢，从而改善血脂谱。白杨素通过增加内皮一氧化氮的生物利用度来调节血管功能。白杨素通过减轻血管炎症来抑制动脉粥样硬化的发展。白杨素的抗炎作用可能与其对核转录因子 -κB 信号通路的抑制作用有关。它还可防止血管平滑肌细胞增殖和血栓形成。总之，白杨素可能作为预防和治疗心血管疾病的天然药物有效；然而，需要进行多项临床试验研究来证实其对人类的保护作用。
